Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency
Adrenal insufficiency is a disease characterized by insufficient secretion of adrenocortical hormones, usually treated with glucocorticoid replacement therapy. The routine drugs have two forms-short-acting and long-acting. The shorter one should be taken 2-3 times a day resulting hormone level of pa...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Rare Diseases
2023-07-01
|
| Series: | 罕见病研究 |
| Subjects: | |
| Online Access: | https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2023.03.016 |
| _version_ | 1797369916017344512 |
|---|---|
| author | CHEN Xiaoxue LI Ran ZHU Huijuan LU Lin |
| author_facet | CHEN Xiaoxue LI Ran ZHU Huijuan LU Lin |
| author_sort | CHEN Xiaoxue |
| collection | DOAJ |
| description | Adrenal insufficiency is a disease characterized by insufficient secretion of adrenocortical hormones, usually treated with glucocorticoid replacement therapy. The routine drugs have two forms-short-acting and long-acting. The shorter one should be taken 2-3 times a day resulting hormone level of patients fluctuating greatly within a day. Although long-acting drugs reduce the frequency of administration, it is easy to lead to excessive replacement, resulting in adverse effects on metabolism. New alternative treatments for adult patients have emerged, including modified-release hydrocortisone and hydrocortisone subcutaneous infusion pumps. In this review, we briefly introduce these new therapies, emphasizing the pharmacodynamics and pharmacokinetics of the replacement, the effects on metabolism and drug safety, aiming at contributing to the future clinical practice. |
| first_indexed | 2024-03-08T17:54:00Z |
| format | Article |
| id | doaj.art-17bdb778a8e6479285a9b04ea8ae97a0 |
| institution | Directory Open Access Journal |
| issn | 2097-0501 |
| language | zho |
| last_indexed | 2024-03-08T17:54:00Z |
| publishDate | 2023-07-01 |
| publisher | Editorial Office of Journal of Rare Diseases |
| record_format | Article |
| series | 罕见病研究 |
| spelling | doaj.art-17bdb778a8e6479285a9b04ea8ae97a02024-01-02T05:50:16ZzhoEditorial Office of Journal of Rare Diseases罕见病研究2097-05012023-07-012343644110.12376/j.issn.2097-0501.2023.03.016Advances in Hormone Replacement Therapy for Adult Adrenal InsufficiencyCHEN XiaoxueLI RanZHU HuijuanLU LinAdrenal insufficiency is a disease characterized by insufficient secretion of adrenocortical hormones, usually treated with glucocorticoid replacement therapy. The routine drugs have two forms-short-acting and long-acting. The shorter one should be taken 2-3 times a day resulting hormone level of patients fluctuating greatly within a day. Although long-acting drugs reduce the frequency of administration, it is easy to lead to excessive replacement, resulting in adverse effects on metabolism. New alternative treatments for adult patients have emerged, including modified-release hydrocortisone and hydrocortisone subcutaneous infusion pumps. In this review, we briefly introduce these new therapies, emphasizing the pharmacodynamics and pharmacokinetics of the replacement, the effects on metabolism and drug safety, aiming at contributing to the future clinical practice.https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2023.03.016adrenal insufficiencyadultglucocorticoidmodified-release hydrocortisonesubcutaneous infusion pump |
| spellingShingle | CHEN Xiaoxue LI Ran ZHU Huijuan LU Lin Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency 罕见病研究 adrenal insufficiency adult glucocorticoid modified-release hydrocortisone subcutaneous infusion pump |
| title | Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency |
| title_full | Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency |
| title_fullStr | Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency |
| title_full_unstemmed | Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency |
| title_short | Advances in Hormone Replacement Therapy for Adult Adrenal Insufficiency |
| title_sort | advances in hormone replacement therapy for adult adrenal insufficiency |
| topic | adrenal insufficiency adult glucocorticoid modified-release hydrocortisone subcutaneous infusion pump |
| url | https://jrd.chard.org.cn/article/doi/10.12376/j.issn.2097-0501.2023.03.016 |
| work_keys_str_mv | AT chenxiaoxue advancesinhormonereplacementtherapyforadultadrenalinsufficiency AT liran advancesinhormonereplacementtherapyforadultadrenalinsufficiency AT zhuhuijuan advancesinhormonereplacementtherapyforadultadrenalinsufficiency AT lulin advancesinhormonereplacementtherapyforadultadrenalinsufficiency |