Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression
Abstract Background TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthes...
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| Format: | Article |
| Language: | English |
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BMC
2017-12-01
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| Series: | Journal of Ovarian Research |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13048-017-0371-y |
| _version_ | 1797966317747175424 |
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| author | Abolfazl Bahrami Seyed Reza Miraie-Ashtiani Mostafa Sadeghi Ali Najafi Reza Ranjbar |
| author_facet | Abolfazl Bahrami Seyed Reza Miraie-Ashtiani Mostafa Sadeghi Ali Najafi Reza Ranjbar |
| author_sort | Abolfazl Bahrami |
| collection | DOAJ |
| description | Abstract Background TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthesis. Results TEK signaling on each of the two important pathways where levels of pERK, pMYC, pAkt, pMCL1 and pEIF4EBP1 are increased in dominant follicles and pMYC is decreased in dominant follicles. Over activation of ERK and MYC which are the main cell growth and proliferation and over activation of Akt, MCl1, mTORC1 and EIF4EBP1 which are the main cell survival and protein synthesis factors act as promoting factors for folliculogenesis. In case of over expression of hsa-miR-30d-3p and hsa-miR-451a, MYC activity level is considerably increased in subordinate follicles. Our simulation results show that in the presence of has-miR-548v and bta-miR-22-3p, downstream factors of pathways are inhibited. Conclusions Our work offers insight into the design of natural biological procedures and makes predictions that can guide further experimental studies on folliculogenesis pathways. Moreover, it defines a simple signal processing unit that may be useful for engineering synthetic biology and genes circuits to carry out cell-based computation. |
| first_indexed | 2024-04-11T02:13:38Z |
| format | Article |
| id | doaj.art-17be9421227e493b8c7622d466689dfb |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T02:13:38Z |
| publishDate | 2017-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Ovarian Research |
| spelling | doaj.art-17be9421227e493b8c7622d466689dfb2023-01-03T01:38:43ZengBMCJournal of Ovarian Research1757-22152017-12-011011910.1186/s13048-017-0371-yDynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expressionAbolfazl Bahrami0Seyed Reza Miraie-Ashtiani1Mostafa Sadeghi2Ali Najafi3Reza Ranjbar4Department of Animal Science, University college of Agriculture and Natural Resources, University of TehranDepartment of Animal Science, University college of Agriculture and Natural Resources, University of TehranDepartment of Animal Science, University college of Agriculture and Natural Resources, University of TehranMolecular Biology Research Center, Baqiyatallah University of Medical SciencesMolecular Biology Research Center, Baqiyatallah University of Medical SciencesAbstract Background TEK signaling plays a very important role in folliculogenesis. It activates Ras/ERK/MYC, PI3K/AKT/mTORC1 and ovarian steroidogenesis activation pathways. These are the main pathways for cell growth, differentiation, migration, adhesion, proliferation, survival and protein synthesis. Results TEK signaling on each of the two important pathways where levels of pERK, pMYC, pAkt, pMCL1 and pEIF4EBP1 are increased in dominant follicles and pMYC is decreased in dominant follicles. Over activation of ERK and MYC which are the main cell growth and proliferation and over activation of Akt, MCl1, mTORC1 and EIF4EBP1 which are the main cell survival and protein synthesis factors act as promoting factors for folliculogenesis. In case of over expression of hsa-miR-30d-3p and hsa-miR-451a, MYC activity level is considerably increased in subordinate follicles. Our simulation results show that in the presence of has-miR-548v and bta-miR-22-3p, downstream factors of pathways are inhibited. Conclusions Our work offers insight into the design of natural biological procedures and makes predictions that can guide further experimental studies on folliculogenesis pathways. Moreover, it defines a simple signal processing unit that may be useful for engineering synthetic biology and genes circuits to carry out cell-based computation.http://link.springer.com/article/10.1186/s13048-017-0371-yDynamic modelingFolliculogenesisTEK signalingRas/ERK/MYCPI3K/AKT/mTORC1 |
| spellingShingle | Abolfazl Bahrami Seyed Reza Miraie-Ashtiani Mostafa Sadeghi Ali Najafi Reza Ranjbar Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression Journal of Ovarian Research Dynamic modeling Folliculogenesis TEK signaling Ras/ERK/MYC PI3K/AKT/mTORC1 |
| title | Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression |
| title_full | Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression |
| title_fullStr | Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression |
| title_full_unstemmed | Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression |
| title_short | Dynamic modeling of folliculogenesis signaling pathways in the presence of miRNAs expression |
| title_sort | dynamic modeling of folliculogenesis signaling pathways in the presence of mirnas expression |
| topic | Dynamic modeling Folliculogenesis TEK signaling Ras/ERK/MYC PI3K/AKT/mTORC1 |
| url | http://link.springer.com/article/10.1186/s13048-017-0371-y |
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