Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction
Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-05-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/11/6/686 |
| _version_ | 1797532975880994816 |
|---|---|
| author | Tom Wai-Hin Chung Hui Zhang Fergus Kai-Chuen Wong Siddharth Sridhar Kwok-Hung Chan Vincent Chi-Chung Cheng Kwok-Yung Yuen Ivan Fan-Ngai Hung Henry Ka-Fung Mak |
| author_facet | Tom Wai-Hin Chung Hui Zhang Fergus Kai-Chuen Wong Siddharth Sridhar Kwok-Hung Chan Vincent Chi-Chung Cheng Kwok-Yung Yuen Ivan Fan-Ngai Hung Henry Ka-Fung Mak |
| author_sort | Tom Wai-Hin Chung |
| collection | DOAJ |
| description | Non-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm<sup>3</sup> to 49.5 mm<sup>3</sup> (120%), left: 37.5 mm<sup>3</sup> to 42 mm<sup>3</sup> (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)]. |
| first_indexed | 2024-03-10T11:08:01Z |
| format | Article |
| id | doaj.art-17c07fea04ba4afb81d8c57b957c2138 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:08:01Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-17c07fea04ba4afb81d8c57b957c21382023-11-21T20:59:37ZengMDPI AGBrain Sciences2076-34252021-05-0111668610.3390/brainsci11060686Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory DysfunctionTom Wai-Hin Chung0Hui Zhang1Fergus Kai-Chuen Wong2Siddharth Sridhar3Kwok-Hung Chan4Vincent Chi-Chung Cheng5Kwok-Yung Yuen6Ivan Fan-Ngai Hung7Henry Ka-Fung Mak8Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Ear, Nose and Throat Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong, ChinaDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaState Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, ChinaDepartment of Diagnostic Radiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaNon-conductive olfactory dysfunction (OD) is an important extra-pulmonary manifestation of coronavirus disease 2019 (COVID-19). Olfactory bulb (OB) volume loss and olfactory network functional connectivity (FC) defects were identified in two patients suffering from prolonged COVID-19-related OD. One patient received olfactory treatment (OT) by the combination of oral vitamin A and smell training via the novel electronic portable aromatic rehabilitation (EPAR) diffusers. After four-weeks of OT, clinical recuperation of smell was correlated with interval increase of bilateral OB volumes [right: 22.5 mm<sup>3</sup> to 49.5 mm<sup>3</sup> (120%), left: 37.5 mm<sup>3</sup> to 42 mm<sup>3</sup> (12%)] and improvement of mean olfactory FC [0.09 to 0.15 (66.6%)].https://www.mdpi.com/2076-3425/11/6/686COVID-19olfactory dysfunctionvitamin Asmell trainingresting-state fMRI |
| spellingShingle | Tom Wai-Hin Chung Hui Zhang Fergus Kai-Chuen Wong Siddharth Sridhar Kwok-Hung Chan Vincent Chi-Chung Cheng Kwok-Yung Yuen Ivan Fan-Ngai Hung Henry Ka-Fung Mak Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction Brain Sciences COVID-19 olfactory dysfunction vitamin A smell training resting-state fMRI |
| title | Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction |
| title_full | Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction |
| title_fullStr | Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction |
| title_full_unstemmed | Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction |
| title_short | Neurosensory Rehabilitation and Olfactory Network Recovery in Covid-19-related Olfactory Dysfunction |
| title_sort | neurosensory rehabilitation and olfactory network recovery in covid 19 related olfactory dysfunction |
| topic | COVID-19 olfactory dysfunction vitamin A smell training resting-state fMRI |
| url | https://www.mdpi.com/2076-3425/11/6/686 |
| work_keys_str_mv | AT tomwaihinchung neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT huizhang neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT ferguskaichuenwong neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT siddharthsridhar neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT kwokhungchan neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT vincentchichungcheng neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT kwokyungyuen neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT ivanfanngaihung neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction AT henrykafungmak neurosensoryrehabilitationandolfactorynetworkrecoveryincovid19relatedolfactorydysfunction |