Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report

Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment with bronchodilators, nutritional support, and pulmonary rehabilitation for frailty in patients with COPD, none have address...

Full description

Bibliographic Details
Main Authors: Hirai Kuniaki, Tanaka Akihiko, Homma Tetsuya, Mikuni Hatsuko, Kawahara Tomoko, Ohta Shin, Kusumoto Sojiro, Yamamoto Mayumi, Yamaguchi Fumihiro, Suzuki Shintaro, Ohnishi Tsukasa, Sagara Hironori
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Nutrition
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnut.2018.00071/full
_version_ 1811300771063398400
author Hirai Kuniaki
Tanaka Akihiko
Homma Tetsuya
Mikuni Hatsuko
Kawahara Tomoko
Ohta Shin
Kusumoto Sojiro
Yamamoto Mayumi
Yamaguchi Fumihiro
Suzuki Shintaro
Ohnishi Tsukasa
Sagara Hironori
author_facet Hirai Kuniaki
Tanaka Akihiko
Homma Tetsuya
Mikuni Hatsuko
Kawahara Tomoko
Ohta Shin
Kusumoto Sojiro
Yamamoto Mayumi
Yamaguchi Fumihiro
Suzuki Shintaro
Ohnishi Tsukasa
Sagara Hironori
author_sort Hirai Kuniaki
collection DOAJ
description Frailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment with bronchodilators, nutritional support, and pulmonary rehabilitation for frailty in patients with COPD, none have addressed the effects of traditional Japanese medicine (Kampo medicine). Herein, we report the successful management of frailty using Ninjin'yoeito therapy in a 76-year-old patient with COPD. Despite being prescribed multiple bronchodilators, nutritional supplement therapy, patient education, and pulmonary rehabilitation, the patient exhibited unintentional weight loss, low energy, and low physical activity. Ninjin'yoeito was prescribed and these subjective symptoms began to improve 1 month after treatment initiation. In 6 months, the patient reported no frailty, had increased muscle mass, and had achieved an almost normal healthy state. Ninjin'yoeito has been associated with both physical effects, such as improvement in overall physical strength and appetite, and reduction in fatigue, and psychological effects, such as greater motivation and reduction of depression and anxiety symptoms. Physicians have usually treated COPD primarily with organ-specific treatments, such as bronchodilators; however, addressing both the physiological and psychological vulnerability has been difficult. This case report illustrates the potential usefulness of Ninjin'yoeito treatment for frailty in patients with COPD.
first_indexed 2024-04-13T06:56:39Z
format Article
id doaj.art-17c09c28d7d24ea69eeb1b9d2d33a505
institution Directory Open Access Journal
issn 2296-861X
language English
last_indexed 2024-04-13T06:56:39Z
publishDate 2018-09-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Nutrition
spelling doaj.art-17c09c28d7d24ea69eeb1b9d2d33a5052022-12-22T02:57:14ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2018-09-01510.3389/fnut.2018.00071404604Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case ReportHirai KuniakiTanaka AkihikoHomma TetsuyaMikuni HatsukoKawahara TomokoOhta ShinKusumoto SojiroYamamoto MayumiYamaguchi FumihiroSuzuki ShintaroOhnishi TsukasaSagara HironoriFrailty is a poor prognostic factor in patients with chronic obstructive pulmonary disease (COPD). Although various studies have assessed the effects of conventional treatment with bronchodilators, nutritional support, and pulmonary rehabilitation for frailty in patients with COPD, none have addressed the effects of traditional Japanese medicine (Kampo medicine). Herein, we report the successful management of frailty using Ninjin'yoeito therapy in a 76-year-old patient with COPD. Despite being prescribed multiple bronchodilators, nutritional supplement therapy, patient education, and pulmonary rehabilitation, the patient exhibited unintentional weight loss, low energy, and low physical activity. Ninjin'yoeito was prescribed and these subjective symptoms began to improve 1 month after treatment initiation. In 6 months, the patient reported no frailty, had increased muscle mass, and had achieved an almost normal healthy state. Ninjin'yoeito has been associated with both physical effects, such as improvement in overall physical strength and appetite, and reduction in fatigue, and psychological effects, such as greater motivation and reduction of depression and anxiety symptoms. Physicians have usually treated COPD primarily with organ-specific treatments, such as bronchodilators; however, addressing both the physiological and psychological vulnerability has been difficult. This case report illustrates the potential usefulness of Ninjin'yoeito treatment for frailty in patients with COPD.https://www.frontiersin.org/article/10.3389/fnut.2018.00071/fullfrailtychronic obstructive pulmonary diseaseNinjin'yoeito therapyKampo medicineanorexia
spellingShingle Hirai Kuniaki
Tanaka Akihiko
Homma Tetsuya
Mikuni Hatsuko
Kawahara Tomoko
Ohta Shin
Kusumoto Sojiro
Yamamoto Mayumi
Yamaguchi Fumihiro
Suzuki Shintaro
Ohnishi Tsukasa
Sagara Hironori
Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
Frontiers in Nutrition
frailty
chronic obstructive pulmonary disease
Ninjin'yoeito therapy
Kampo medicine
anorexia
title Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
title_full Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
title_fullStr Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
title_full_unstemmed Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
title_short Improvement in Frailty in a Patient With Severe Chronic Obstructive Pulmonary Disease After Ninjin'yoeito Therapy: A Case Report
title_sort improvement in frailty in a patient with severe chronic obstructive pulmonary disease after ninjin yoeito therapy a case report
topic frailty
chronic obstructive pulmonary disease
Ninjin'yoeito therapy
Kampo medicine
anorexia
url https://www.frontiersin.org/article/10.3389/fnut.2018.00071/full
work_keys_str_mv AT hiraikuniaki improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT tanakaakihiko improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT hommatetsuya improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT mikunihatsuko improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT kawaharatomoko improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT ohtashin improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT kusumotosojiro improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT yamamotomayumi improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT yamaguchifumihiro improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT suzukishintaro improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT ohnishitsukasa improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport
AT sagarahironori improvementinfrailtyinapatientwithseverechronicobstructivepulmonarydiseaseafterninjinyoeitotherapyacasereport