Pregnancy- and lactation-induced osteoporosis: a social-media-based survey
Abstract Background Pregnancy- and lactation-induced osteoporosis (PLO) presenting as spinal fractures is rare, and the spectrum of clinical presentation, risk factors and pathophysiology are incompletely understood. The aim of this study was to delineate clinical parameters, risk factors and osteop...
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-05639-w |
| _version_ | 1797831798548332544 |
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| author | Naama Peltz-Sinvani Hadar Milloh Raz Pinchas Klein Sophia Ish-Shalom Iris Vered Liana Tripto-Shkolnik |
| author_facet | Naama Peltz-Sinvani Hadar Milloh Raz Pinchas Klein Sophia Ish-Shalom Iris Vered Liana Tripto-Shkolnik |
| author_sort | Naama Peltz-Sinvani |
| collection | DOAJ |
| description | Abstract Background Pregnancy- and lactation-induced osteoporosis (PLO) presenting as spinal fractures is rare, and the spectrum of clinical presentation, risk factors and pathophysiology are incompletely understood. The aim of this study was to delineate clinical parameters, risk factors and osteoporosis-related quality of life (QOL) of women with PLO. Methods Participants of a social-media (WhatsApp) PLO group and mothers of a parents’ WhatsApp group (control group) were offered to fill a questionnaire, including an osteoporosis-related QOL section. The groups were compared using the independent Students t test for numerical variables, and the Chi-square test or Fisher’s exact test for categorical variables. Results Twenty-seven women with PLO and 43 in the control group (aged 36.2 ± 4.7 and 38.8 ± 4.3 years, respectively, p = 0.04) participated. Among women with PLO, more than 5 vertebrae were involved in 13 (48%), 4 vertebrae in 6 (22%), and 3 or fewer vertebrae in 8 (30%). Among the 24 women with relevant data, 21 (88%) had nontraumatic fractures; 3 (13%) women had fractures during pregnancy, and the remaining during the early postpartum period. Diagnosis was delayed for over 16 weeks for 11 (41%) women; 16 (67%) received teriparatide. Significantly lower proportions of women in the PLO group engaged in physical activity over 2 hours/week, before and during pregnancy (37 vs. 67%, p < 0.015 and 11 vs. 44%, p < 0.003, respectively). A lower proportion of the PLO than the control group reported calcium supplementation during pregnancy (7% vs. 30%, p = 0.03) and a higher proportion reported treatment with low-molecular-weight-heparin during pregnancy (p = 0.03). Eighteen (67%) of the PLO group expressed fear of fractures and 15 (56%) fear of falls, compared to none and 2%, respectively, of the control group (p < 0.00001 for both). Conclusions Most of the women with PLO who responded to our survey reported spinal fractures involving multiple vertebrae, delayed diagnosis, and treatment with teriparatide. Compared to a control group, they reported less physical activity and impaired QOL. For this uncommon yet severe condition, a multidisciplinary effort should be exerted for early identification and treatment, to alleviate back pain, prevent subsequent fractures and improve QOL. |
| first_indexed | 2024-04-09T13:58:33Z |
| format | Article |
| id | doaj.art-17c0a28f7ecb4b5881a2720b4e21abf3 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-09T13:58:33Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-17c0a28f7ecb4b5881a2720b4e21abf32023-05-07T11:26:48ZengBMCBMC Pregnancy and Childbirth1471-23932023-05-012311610.1186/s12884-023-05639-wPregnancy- and lactation-induced osteoporosis: a social-media-based surveyNaama Peltz-Sinvani0Hadar Milloh Raz1Pinchas Klein2Sophia Ish-Shalom3Iris Vered4Liana Tripto-Shkolnik5Division of Endocrinology, Diabetes and Metabolism, Sheba Medical CenterDivision of Endocrinology, Diabetes and Metabolism, Sheba Medical CenterDivision of Endocrinology, Diabetes and Metabolism, Sheba Medical CenterElisha HospitalDivision of Endocrinology, Diabetes and Metabolism, Sheba Medical CenterDivision of Endocrinology, Diabetes and Metabolism, Sheba Medical CenterAbstract Background Pregnancy- and lactation-induced osteoporosis (PLO) presenting as spinal fractures is rare, and the spectrum of clinical presentation, risk factors and pathophysiology are incompletely understood. The aim of this study was to delineate clinical parameters, risk factors and osteoporosis-related quality of life (QOL) of women with PLO. Methods Participants of a social-media (WhatsApp) PLO group and mothers of a parents’ WhatsApp group (control group) were offered to fill a questionnaire, including an osteoporosis-related QOL section. The groups were compared using the independent Students t test for numerical variables, and the Chi-square test or Fisher’s exact test for categorical variables. Results Twenty-seven women with PLO and 43 in the control group (aged 36.2 ± 4.7 and 38.8 ± 4.3 years, respectively, p = 0.04) participated. Among women with PLO, more than 5 vertebrae were involved in 13 (48%), 4 vertebrae in 6 (22%), and 3 or fewer vertebrae in 8 (30%). Among the 24 women with relevant data, 21 (88%) had nontraumatic fractures; 3 (13%) women had fractures during pregnancy, and the remaining during the early postpartum period. Diagnosis was delayed for over 16 weeks for 11 (41%) women; 16 (67%) received teriparatide. Significantly lower proportions of women in the PLO group engaged in physical activity over 2 hours/week, before and during pregnancy (37 vs. 67%, p < 0.015 and 11 vs. 44%, p < 0.003, respectively). A lower proportion of the PLO than the control group reported calcium supplementation during pregnancy (7% vs. 30%, p = 0.03) and a higher proportion reported treatment with low-molecular-weight-heparin during pregnancy (p = 0.03). Eighteen (67%) of the PLO group expressed fear of fractures and 15 (56%) fear of falls, compared to none and 2%, respectively, of the control group (p < 0.00001 for both). Conclusions Most of the women with PLO who responded to our survey reported spinal fractures involving multiple vertebrae, delayed diagnosis, and treatment with teriparatide. Compared to a control group, they reported less physical activity and impaired QOL. For this uncommon yet severe condition, a multidisciplinary effort should be exerted for early identification and treatment, to alleviate back pain, prevent subsequent fractures and improve QOL.https://doi.org/10.1186/s12884-023-05639-wOsteoporosisPregnancyLactationVertebral fractureQuality of life |
| spellingShingle | Naama Peltz-Sinvani Hadar Milloh Raz Pinchas Klein Sophia Ish-Shalom Iris Vered Liana Tripto-Shkolnik Pregnancy- and lactation-induced osteoporosis: a social-media-based survey BMC Pregnancy and Childbirth Osteoporosis Pregnancy Lactation Vertebral fracture Quality of life |
| title | Pregnancy- and lactation-induced osteoporosis: a social-media-based survey |
| title_full | Pregnancy- and lactation-induced osteoporosis: a social-media-based survey |
| title_fullStr | Pregnancy- and lactation-induced osteoporosis: a social-media-based survey |
| title_full_unstemmed | Pregnancy- and lactation-induced osteoporosis: a social-media-based survey |
| title_short | Pregnancy- and lactation-induced osteoporosis: a social-media-based survey |
| title_sort | pregnancy and lactation induced osteoporosis a social media based survey |
| topic | Osteoporosis Pregnancy Lactation Vertebral fracture Quality of life |
| url | https://doi.org/10.1186/s12884-023-05639-w |
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