Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells

Modified mRNA vaccines have developed into an effective and well-tolerated vaccine platform that offers scalable and precise antigen production. Nevertheless, the immunological events leading to strong antibody responses elicited by mRNA vaccines are largely unknown. In this study, we demonstrate th...

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Bibliographic Details
Main Authors: Gustaf Lindgren, Sebastian Ols, Frank Liang, Elizabeth A. Thompson, Ang Lin, Fredrika Hellgren, Kapil Bahl, Shinu John, Olga Yuzhakov, Kimberly J. Hassett, Luis A. Brito, Hugh Salter, Giuseppe Ciaramella, Karin Loré
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Immunology
Subjects:
mRNA vaccine
adaptive immune responses
non-human primates
influenza
T follicular helper cells
germinal centers
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01539/full

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