Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light
Blue LED light has proven to have a powerful bacteria-killing ability; however, little is known about its mechanism of virucidal activity. Therefore, we analyzed the effect of blue light on different respiratory viruses, such as adenovirus, respiratory syncytial virus and SARS-CoV-2. The exposure of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/10/12/1590 |
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| author | Chiara Terrosi Gabriele Anichini Jean Denis Docquier Gianni Gori Savellini Claudia Gandolfo Francesco Saverio Pavone Maria Grazia Cusi |
| author_facet | Chiara Terrosi Gabriele Anichini Jean Denis Docquier Gianni Gori Savellini Claudia Gandolfo Francesco Saverio Pavone Maria Grazia Cusi |
| author_sort | Chiara Terrosi |
| collection | DOAJ |
| description | Blue LED light has proven to have a powerful bacteria-killing ability; however, little is known about its mechanism of virucidal activity. Therefore, we analyzed the effect of blue light on different respiratory viruses, such as adenovirus, respiratory syncytial virus and SARS-CoV-2. The exposure of samples to a blue LED light with a wavelength of 420 nm (i.e., in the visible range) at 20 mW/cm<sup>2</sup> of irradiance for 15 min appeared optimal and resulted in the complete inactivation of the viral load. These results were similar for all the three viruses, demonstrating that both enveloped and naked viruses could be efficiently inactivated with blue LED light, regardless of the presence of envelope and of the viral genome nature (DNA or RNA). Moreover, we provided some explanations to the mechanisms by which the blue LED light could exert its antiviral activity. The development of such safe and low-cost light-based devices appears to be of fundamental utility for limiting viral spread and for sanitizing small environments, objects and surfaces, especially in the pandemic era. |
| first_indexed | 2024-03-10T03:21:09Z |
| format | Article |
| id | doaj.art-17c2fa10aeda49f18523094782bc87d9 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T03:21:09Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-17c2fa10aeda49f18523094782bc87d92023-11-23T10:01:07ZengMDPI AGPathogens2076-08172021-12-011012159010.3390/pathogens10121590Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED LightChiara Terrosi0Gabriele Anichini1Jean Denis Docquier2Gianni Gori Savellini3Claudia Gandolfo4Francesco Saverio Pavone5Maria Grazia Cusi6Department of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyDepartment of Physics and Astronomy, European Laboratory for Non Linear Spectroscopy (LENS), University of Florence, 50121 Florence, ItalyDepartment of Medical Biotechnologies, University of Siena, 53100 Siena, ItalyBlue LED light has proven to have a powerful bacteria-killing ability; however, little is known about its mechanism of virucidal activity. Therefore, we analyzed the effect of blue light on different respiratory viruses, such as adenovirus, respiratory syncytial virus and SARS-CoV-2. The exposure of samples to a blue LED light with a wavelength of 420 nm (i.e., in the visible range) at 20 mW/cm<sup>2</sup> of irradiance for 15 min appeared optimal and resulted in the complete inactivation of the viral load. These results were similar for all the three viruses, demonstrating that both enveloped and naked viruses could be efficiently inactivated with blue LED light, regardless of the presence of envelope and of the viral genome nature (DNA or RNA). Moreover, we provided some explanations to the mechanisms by which the blue LED light could exert its antiviral activity. The development of such safe and low-cost light-based devices appears to be of fundamental utility for limiting viral spread and for sanitizing small environments, objects and surfaces, especially in the pandemic era.https://www.mdpi.com/2076-0817/10/12/1590blue LED lightSARS-CoV-2adenovirusrespiratory syncytial virusviral inactivation |
| spellingShingle | Chiara Terrosi Gabriele Anichini Jean Denis Docquier Gianni Gori Savellini Claudia Gandolfo Francesco Saverio Pavone Maria Grazia Cusi Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light Pathogens blue LED light SARS-CoV-2 adenovirus respiratory syncytial virus viral inactivation |
| title | Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light |
| title_full | Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light |
| title_fullStr | Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light |
| title_full_unstemmed | Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light |
| title_short | Efficient Inactivation of SARS-CoV-2 and Other RNA or DNA Viruses with Blue LED Light |
| title_sort | efficient inactivation of sars cov 2 and other rna or dna viruses with blue led light |
| topic | blue LED light SARS-CoV-2 adenovirus respiratory syncytial virus viral inactivation |
| url | https://www.mdpi.com/2076-0817/10/12/1590 |
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