Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients
Background: Coronavirus disease-19 (COVID-19) has sparked the deterioration of human health at an unprecedented scale globally and affected the patient’s musculoskeletal health also. It is conceivable that active rheumatoid arthritis (ARA) patients recovered from COVID-19 after second wave are at en...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Manipal College of Medical Sciences, Pokhara
2022-11-01
|
| Series: | Asian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/46933 |
| _version_ | 1811325700373741568 |
|---|---|
| author | Merajul Haque Siddiqui Jugal Kishor Agarwal Dipty Agrawal Rahul Saxena Rajni Ranjan Bhumesh Tyagi |
| author_facet | Merajul Haque Siddiqui Jugal Kishor Agarwal Dipty Agrawal Rahul Saxena Rajni Ranjan Bhumesh Tyagi |
| author_sort | Merajul Haque Siddiqui |
| collection | DOAJ |
| description | Background: Coronavirus disease-19 (COVID-19) has sparked the deterioration of human health at an unprecedented scale globally and affected the patient’s musculoskeletal health also. It is conceivable that active rheumatoid arthritis (ARA) patients recovered from COVID-19 after second wave are at enhanced risk of cardiovascular complications.
Aim and Objectives: In this context, the present study was intended to estimate the soluble vascular cell adhesion molecule-1 (sVCAM-1), serum paraoxonase (PON), and markers of oxi-inflammatory stress in ARA patients diagnosed reverse transcriptase-polymerase chain reaction negative after second wave of COVID-19 and to determine their role in predicting cardiovascular disease (CVD) risk.
Materials and Methods: Sixty ARA patients (30–45 years) of Delhi-NCR region were recruited and categorized into two groups (n=30 in each group; on the basis of their history of COVID infection). Using standard methods, study group parameters were estimated in ARA patients and statistically compared it with that of 30 healthy controls by using student’s t-test.
Results: Serum sVCAM-1, malondialdehyde (MDA), and C-reactive protein (CRP) levels were significantly high (P<0.001) in Group II and Group III subjects as compared to healthy controls. Conversely, serum PON activity was found to be significantly low (P<0.001) in Group III as compared healthy controls. However, PON activity was altered insignificantly (P<0.1) with respect to Group II subjects. sVCAM-1 levels were positively correlated with MDA, CRP, and atherogenic index; and negatively correlated with PON activity (P<0.001) in post-COVID ARA patients.
Conclusion: Thus, enhanced sVCAM-1 and reduced PON activity along with enhanced oxi-inflammatory stress status are more efficient molecular signatures of CVD risk among post-COVID ARA patients. Therefore, the present study emphasizes the dire need of special attention to provide cardiovascular rehabilitation strategy among post-COVID ARA patients along with reduction of oxi-inflammatory stress to reduce the CVD mortality in ARA population. |
| first_indexed | 2024-04-13T14:37:36Z |
| format | Article |
| id | doaj.art-17c389561bfd4b0aaee4a93b1549cd74 |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-04-13T14:37:36Z |
| publishDate | 2022-11-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-17c389561bfd4b0aaee4a93b1549cd742022-12-22T02:42:59ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762022-11-011311310https://doi.org/10.3126/ajms.v13i11.46933Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patientsMerajul Haque Siddiqui 0https://orcid.org/0000-0001-7551-1970Jugal Kishor Agarwal 1https://orcid.org/0000-0001-8387-9927Dipty Agrawal 2https://orcid.org/0000-0003-0853-9388Rahul Saxena 3https://orcid.org/0000-0002-4517-8529Rajni Ranjan 4https://orcid.org/0000-0003-2324-6970Bhumesh Tyagi 5https://orcid.org/0000-0002-9296-0310Assistant Professor, Department of Biochemistry, Saraswati Institute of Medical Sciences, Hapur, Uttar Pradesh, India Assistant Professor, Department of Microbiology, Rama Medical College Hospital and Research Centre, Hapur, Uttar Pradesh, India Assistant Professor, Department of Anaesthesia, Rama Medical College Hospital and Research Centre, Hapur, Uttar Pradesh, India Professor, Department of Biochemistry, School of Allied Health Sciences, Sharda University, Greater Noida, Uttar Pradesh, India Professor, Department of Orthopedics, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India Assistant Professor, Department of Medicine, School of Medical Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India Background: Coronavirus disease-19 (COVID-19) has sparked the deterioration of human health at an unprecedented scale globally and affected the patient’s musculoskeletal health also. It is conceivable that active rheumatoid arthritis (ARA) patients recovered from COVID-19 after second wave are at enhanced risk of cardiovascular complications. Aim and Objectives: In this context, the present study was intended to estimate the soluble vascular cell adhesion molecule-1 (sVCAM-1), serum paraoxonase (PON), and markers of oxi-inflammatory stress in ARA patients diagnosed reverse transcriptase-polymerase chain reaction negative after second wave of COVID-19 and to determine their role in predicting cardiovascular disease (CVD) risk. Materials and Methods: Sixty ARA patients (30–45 years) of Delhi-NCR region were recruited and categorized into two groups (n=30 in each group; on the basis of their history of COVID infection). Using standard methods, study group parameters were estimated in ARA patients and statistically compared it with that of 30 healthy controls by using student’s t-test. Results: Serum sVCAM-1, malondialdehyde (MDA), and C-reactive protein (CRP) levels were significantly high (P<0.001) in Group II and Group III subjects as compared to healthy controls. Conversely, serum PON activity was found to be significantly low (P<0.001) in Group III as compared healthy controls. However, PON activity was altered insignificantly (P<0.1) with respect to Group II subjects. sVCAM-1 levels were positively correlated with MDA, CRP, and atherogenic index; and negatively correlated with PON activity (P<0.001) in post-COVID ARA patients. Conclusion: Thus, enhanced sVCAM-1 and reduced PON activity along with enhanced oxi-inflammatory stress status are more efficient molecular signatures of CVD risk among post-COVID ARA patients. Therefore, the present study emphasizes the dire need of special attention to provide cardiovascular rehabilitation strategy among post-COVID ARA patients along with reduction of oxi-inflammatory stress to reduce the CVD mortality in ARA population.https://www.nepjol.info/index.php/AJMS/article/view/46933vascular cell adhesion molecule-1; interleukin-6; malondialdehyde; paraoxonase; inflammation; free radicals |
| spellingShingle | Merajul Haque Siddiqui Jugal Kishor Agarwal Dipty Agrawal Rahul Saxena Rajni Ranjan Bhumesh Tyagi Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients Asian Journal of Medical Sciences vascular cell adhesion molecule-1; interleukin-6; malondialdehyde; paraoxonase; inflammation; free radicals |
| title | Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients |
| title_full | Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients |
| title_fullStr | Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients |
| title_full_unstemmed | Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients |
| title_short | Oxi-inflammatory stress and vascular cell adhesion molecule-1 in post-COVID active rheumatoid arthritis patients |
| title_sort | oxi inflammatory stress and vascular cell adhesion molecule 1 in post covid active rheumatoid arthritis patients |
| topic | vascular cell adhesion molecule-1; interleukin-6; malondialdehyde; paraoxonase; inflammation; free radicals |
| url | https://www.nepjol.info/index.php/AJMS/article/view/46933 |
| work_keys_str_mv | AT merajulhaquesiddiqui oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients AT jugalkishoragarwal oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients AT diptyagrawal oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients AT rahulsaxena oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients AT rajniranjan oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients AT bhumeshtyagi oxiinflammatorystressandvascularcelladhesionmolecule1inpostcovidactiverheumatoidarthritispatients |