Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways
Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatmen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/12/3205 |
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| author | Arshad Husain Rahmani Ahmad Almatroudi Khaled S. Allemailem Hajed Obaid A. Alharbi Wanian M. Alwanian Basmah Awwadh Alhunayhani Mohammad Algahtani Abdulrahman Theyab Nahlah Makki Almansour Ahmed N. Algefary Solaiman Saleh Ali Aldeghaim Amjad Ali Khan |
| author_facet | Arshad Husain Rahmani Ahmad Almatroudi Khaled S. Allemailem Hajed Obaid A. Alharbi Wanian M. Alwanian Basmah Awwadh Alhunayhani Mohammad Algahtani Abdulrahman Theyab Nahlah Makki Almansour Ahmed N. Algefary Solaiman Saleh Ali Aldeghaim Amjad Ali Khan |
| author_sort | Arshad Husain Rahmani |
| collection | DOAJ |
| description | Cancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatments such as surgery, chemotherapy, and radiotherapy are effective, but, still, cancer is a major problem leading to death and other side effects. However, safer and effective treatment modules are needed to overcome the adverse effects of current treatment modules. In this regard, natural compounds have been recognized to ameliorate diseases by exerting anti-inflammatory, anti-oxidative, and anti-tumor potential through several mechanisms. Mangiferin, a xanthone C-glucoside, is found in several plant species including <i>Mangifera indica</i> (mango), and its role in disease prevention has been confirmed through its antioxidant and anti-inflammatory properties. Furthermore, its anti-cancer-potential mechanism has been designated through modulation of cell signaling pathways such as inflammation, angiogenesis, PI3K/AKT, apoptosis, and cell cycle. This article extensively reviews the anticancer potential of mangiferin in different cancers through the modulation of cell signaling pathways. Moreover, the synergistic effects of this compound with some commonly used anti-cancer drugs against different cancer cells are discussed. More clinical trials should be performed to reconnoiter the anti-cancer potential of this compound in human cancer treatment. Further, understanding of mechanisms of action and the safety level of this compound can help to manage diseases, including cancer. |
| first_indexed | 2024-03-08T20:58:22Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T20:58:22Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-17c591fce2314cd7917180b7e1525d182023-12-22T13:54:57ZengMDPI AGBiomedicines2227-90592023-12-011112320510.3390/biomedicines11123205Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction PathwaysArshad Husain Rahmani0Ahmad Almatroudi1Khaled S. Allemailem2Hajed Obaid A. Alharbi3Wanian M. Alwanian4Basmah Awwadh Alhunayhani5Mohammad Algahtani6Abdulrahman Theyab7Nahlah Makki Almansour8Ahmed N. Algefary9Solaiman Saleh Ali Aldeghaim10Amjad Ali Khan11Department of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Laboratory & Blood Bank, Security Forces Hospital, P.O. Box 14799, Mecca 21955, Saudi ArabiaDepartment of Laboratory & Blood Bank, Security Forces Hospital, P.O. Box 14799, Mecca 21955, Saudi ArabiaDepartment of Biology, College of Science, University of Hafr Al Batin, Hafr Al Batin 31991, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Medical Laboratories, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaDepartment of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi ArabiaCancer is a major public health concern worldwide in terms of mortality. The exact reason behind the development of cancer is not understood clearly, but it is evidenced that alcohol consumption, radiation, and exposure to chemicals are main players in this pathogenesis. The current mode of treatments such as surgery, chemotherapy, and radiotherapy are effective, but, still, cancer is a major problem leading to death and other side effects. However, safer and effective treatment modules are needed to overcome the adverse effects of current treatment modules. In this regard, natural compounds have been recognized to ameliorate diseases by exerting anti-inflammatory, anti-oxidative, and anti-tumor potential through several mechanisms. Mangiferin, a xanthone C-glucoside, is found in several plant species including <i>Mangifera indica</i> (mango), and its role in disease prevention has been confirmed through its antioxidant and anti-inflammatory properties. Furthermore, its anti-cancer-potential mechanism has been designated through modulation of cell signaling pathways such as inflammation, angiogenesis, PI3K/AKT, apoptosis, and cell cycle. This article extensively reviews the anticancer potential of mangiferin in different cancers through the modulation of cell signaling pathways. Moreover, the synergistic effects of this compound with some commonly used anti-cancer drugs against different cancer cells are discussed. More clinical trials should be performed to reconnoiter the anti-cancer potential of this compound in human cancer treatment. Further, understanding of mechanisms of action and the safety level of this compound can help to manage diseases, including cancer.https://www.mdpi.com/2227-9059/11/12/3205mangiferininflammationpathogenesiscancer therapysignal transduction pathways |
| spellingShingle | Arshad Husain Rahmani Ahmad Almatroudi Khaled S. Allemailem Hajed Obaid A. Alharbi Wanian M. Alwanian Basmah Awwadh Alhunayhani Mohammad Algahtani Abdulrahman Theyab Nahlah Makki Almansour Ahmed N. Algefary Solaiman Saleh Ali Aldeghaim Amjad Ali Khan Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways Biomedicines mangiferin inflammation pathogenesis cancer therapy signal transduction pathways |
| title | Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways |
| title_full | Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways |
| title_fullStr | Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways |
| title_full_unstemmed | Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways |
| title_short | Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways |
| title_sort | role of mangiferin in management of cancers through modulation of signal transduction pathways |
| topic | mangiferin inflammation pathogenesis cancer therapy signal transduction pathways |
| url | https://www.mdpi.com/2227-9059/11/12/3205 |
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