Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation
This study reports a case of hepatoblastoma with onset at 30-weeks' gestation and rapid growth rate. The postnatal enhanced CT confirmed an intrahepatic mass with a size of 8.5 cm × 6.6 cm and a clear boundary accompanied by uneven enhancement, displacement, and narrow lumen of the hepatic vein...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.905089/full |
| _version_ | 1818236108849283072 |
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| author | Zheng Yan Wei Bai Li Li Shuo Li Ying Hua Xiao-xiao Zhang Xin-lin Hou |
| author_facet | Zheng Yan Wei Bai Li Li Shuo Li Ying Hua Xiao-xiao Zhang Xin-lin Hou |
| author_sort | Zheng Yan |
| collection | DOAJ |
| description | This study reports a case of hepatoblastoma with onset at 30-weeks' gestation and rapid growth rate. The postnatal enhanced CT confirmed an intrahepatic mass with a size of 8.5 cm × 6.6 cm and a clear boundary accompanied by uneven enhancement, displacement, and narrow lumen of the hepatic vein due to compression. The alpha-fetoprotein (AFP) at birth was 1,002,632 ng/ml (normal level 48,406 [±34,718] ng/ml). A diagnosis of congenital hepatoblastoma was established based on the imaging and laboratory outcomes. The infant received chemotherapy of Cisplatin-5 fluorouracil-Vincristine (C5V) on the fourth day after birth. After four courses of C5V, a complete tumor resection was performed, and the postoperative pathology was consistent with mixed epithelial and mesenchymal hepatoblastoma. Four more courses of C5V and one course of C5VD (C5V plus doxorubicin) followed the surgery. Infectious diarrhea and acute kidney injury (stage I) occurred during chemotherapy, which recovered after anti-infection and symptomatic treatment. The patient is currently 2 years old and still in complete remission. In this case, the onset of hepatoblastoma was early, and the tumor grew rapidly, resulting in an obvious compression effect. Chemotherapy was started early after birth, and the curative effect was satisfactory, suggesting that the hepatoblastoma based on clinical diagnosis with rapid tumor progression and severe dysfunction of surrounding organs caused by compression should undergo chemotherapy as soon as possible if a pathological diagnosis cannot be obtained temporarily, which also plays an important role in improving the complete resection rate of intraoperative tumor and reducing the recurrence rate of postoperative tumor. |
| first_indexed | 2024-12-12T12:04:38Z |
| format | Article |
| id | doaj.art-17c597776fd64d06907af56f52a6e6b1 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-12T12:04:38Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-17c597776fd64d06907af56f52a6e6b12022-12-22T00:25:01ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-07-011010.3389/fped.2022.905089905089Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' GestationZheng Yan0Wei Bai1Li Li2Shuo Li3Ying Hua4Xiao-xiao Zhang5Xin-lin Hou6Department of Pediatrics, Peking University First Hospital, Beijing, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing, ChinaDepartment of Obstetrics and Gynecology, Peking University First Hospital, Beijing, ChinaDepartment of Pediatrics, Peking University First Hospital, Beijing, ChinaThis study reports a case of hepatoblastoma with onset at 30-weeks' gestation and rapid growth rate. The postnatal enhanced CT confirmed an intrahepatic mass with a size of 8.5 cm × 6.6 cm and a clear boundary accompanied by uneven enhancement, displacement, and narrow lumen of the hepatic vein due to compression. The alpha-fetoprotein (AFP) at birth was 1,002,632 ng/ml (normal level 48,406 [±34,718] ng/ml). A diagnosis of congenital hepatoblastoma was established based on the imaging and laboratory outcomes. The infant received chemotherapy of Cisplatin-5 fluorouracil-Vincristine (C5V) on the fourth day after birth. After four courses of C5V, a complete tumor resection was performed, and the postoperative pathology was consistent with mixed epithelial and mesenchymal hepatoblastoma. Four more courses of C5V and one course of C5VD (C5V plus doxorubicin) followed the surgery. Infectious diarrhea and acute kidney injury (stage I) occurred during chemotherapy, which recovered after anti-infection and symptomatic treatment. The patient is currently 2 years old and still in complete remission. In this case, the onset of hepatoblastoma was early, and the tumor grew rapidly, resulting in an obvious compression effect. Chemotherapy was started early after birth, and the curative effect was satisfactory, suggesting that the hepatoblastoma based on clinical diagnosis with rapid tumor progression and severe dysfunction of surrounding organs caused by compression should undergo chemotherapy as soon as possible if a pathological diagnosis cannot be obtained temporarily, which also plays an important role in improving the complete resection rate of intraoperative tumor and reducing the recurrence rate of postoperative tumor.https://www.frontiersin.org/articles/10.3389/fped.2022.905089/fullalpha-fetoprotein (AFP)chemotherapycongenital hepatoblastomarecurrencesurgery |
| spellingShingle | Zheng Yan Wei Bai Li Li Shuo Li Ying Hua Xiao-xiao Zhang Xin-lin Hou Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation Frontiers in Pediatrics alpha-fetoprotein (AFP) chemotherapy congenital hepatoblastoma recurrence surgery |
| title | Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation |
| title_full | Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation |
| title_fullStr | Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation |
| title_full_unstemmed | Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation |
| title_short | Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation |
| title_sort | case report of congenital hepatoblastoma with the onset at 30 weeks gestation |
| topic | alpha-fetoprotein (AFP) chemotherapy congenital hepatoblastoma recurrence surgery |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.905089/full |
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