Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery

Quality by Design (QbD) and Design of Experiments (DOE) as a Strategy for Tuning Lipid Nanoparticle Formulations for RNA Delivery

The successful development of nonviral delivery systems for nucleic acids has been reported extensively over the past years. Increasingly employed to improve the delivery efficiency and therapeutic efficacy of RNA are lipid nanoparticles (LNPs). Many of the various critical formulation parameters ca...

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Bibliographic Details
Main Authors:	Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Damian A. Smuga, Krzysztof Dubiel, Maciej Wieczorek
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	Biomedicines
Subjects:	quality by design (QbD) design of experiment (DOE) lipid nanoparticle (LNP) RNA delivery
Online Access:	https://www.mdpi.com/2227-9059/11/10/2752

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