Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand
IntroductionThis study aimed to investigate factors associated with time-to-referral due to worsening symptoms in patients with laboratory-confirmed COVID-19 in southern Thailand. While underlying diseases have been evaluated to assess COVID-19 severity, the influence of vaccinations and treatments...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1350304/full |
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| author | Thanit Sila Thanit Sila Wisanuwee Suriyaamorn Chanavee Toh Songyos Rajborirug Smonrapat Surasombatpattana Paramee Thongsuksai Paramee Thongsuksai Chanon Kongkamol Chanon Kongkamol Sarunyou Chusri Phoomjai Sornsenee Prasit Wuthisuthimethawee Raya Chaowanawong Surasak Sangkhathat Surasak Sangkhathat Thammasin Ingviya Thammasin Ingviya |
| author_facet | Thanit Sila Thanit Sila Wisanuwee Suriyaamorn Chanavee Toh Songyos Rajborirug Smonrapat Surasombatpattana Paramee Thongsuksai Paramee Thongsuksai Chanon Kongkamol Chanon Kongkamol Sarunyou Chusri Phoomjai Sornsenee Prasit Wuthisuthimethawee Raya Chaowanawong Surasak Sangkhathat Surasak Sangkhathat Thammasin Ingviya Thammasin Ingviya |
| author_sort | Thanit Sila |
| collection | DOAJ |
| description | IntroductionThis study aimed to investigate factors associated with time-to-referral due to worsening symptoms in patients with laboratory-confirmed COVID-19 in southern Thailand. While underlying diseases have been evaluated to assess COVID-19 severity, the influence of vaccinations and treatments is also crucial.MethodsA cohort of 8,638 patients quarantined in home or community isolation with laboratory-confirmed COVID-19 was analyzed. Survival analysis and the Cox proportional hazard ratio were employed to assess factors influencing time-toreferral.ResultsAge ≥ 60 years, neurologic disorders, cardiovascular disease, and human immunodeficiency virus infection were identified as significant risk factors for severe COVID-19 referral. Patients who received full- or booster-dose vaccinations had a lower risk of experiencing severe symptoms compared to unvaccinated patients. Notably, individuals vaccinated during the Omicron-dominant period had a substantially lower time-to-referral than those unvaccinated during the Delta-dominant period. Moreover, patients vaccinated between 1 and 6 months prior to infection had a significantly lower risk of time-to-referral than the reference group.DiscussionThese findings demonstrate early intervention in high-risk COVID-19 patients and the importance of vaccination efficacy to reduce symptom severity. The study provides valuable insights for guiding future epidemic management strategies and optimising patient care during infectious disease outbreaks. |
| first_indexed | 2024-04-24T22:22:07Z |
| format | Article |
| id | doaj.art-17c96312dca644be873b9d4d38deecad |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-24T22:22:07Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-17c96312dca644be873b9d4d38deecad2024-03-20T05:16:41ZengFrontiers Media S.A.Frontiers in Public Health2296-25652024-03-011210.3389/fpubh.2024.13503041350304Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern ThailandThanit Sila0Thanit Sila1Wisanuwee Suriyaamorn2Chanavee Toh3Songyos Rajborirug4Smonrapat Surasombatpattana5Paramee Thongsuksai6Paramee Thongsuksai7Chanon Kongkamol8Chanon Kongkamol9Sarunyou Chusri10Phoomjai Sornsenee11Prasit Wuthisuthimethawee12Raya Chaowanawong13Surasak Sangkhathat14Surasak Sangkhathat15Thammasin Ingviya16Thammasin Ingviya17Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Health Science and Clinical Research, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDivision of Digital Innovation and Data Analytics, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Health Science and Clinical Research, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Epidemiology, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Health Science and Clinical Research, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDivision of Digital Innovation and Data Analytics, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Internal Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandFaculty of Medicine, Department of Family Medicine and Preventive Medicine, Prince of Songkla University, Hat Yai, Songkla, ThailandDepartment of Emergency Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, ThailandFaculty of Nursing, Prince of Songkla University, Hat Yai, Songkla, Thailand0Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand1Faculty of Medicine, Translational Medicine Research Center, Prince of Songkla University, Songkhla, ThailandDivision of Digital Innovation and Data Analytics, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandDepartment of Family Medicine and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, ThailandIntroductionThis study aimed to investigate factors associated with time-to-referral due to worsening symptoms in patients with laboratory-confirmed COVID-19 in southern Thailand. While underlying diseases have been evaluated to assess COVID-19 severity, the influence of vaccinations and treatments is also crucial.MethodsA cohort of 8,638 patients quarantined in home or community isolation with laboratory-confirmed COVID-19 was analyzed. Survival analysis and the Cox proportional hazard ratio were employed to assess factors influencing time-toreferral.ResultsAge ≥ 60 years, neurologic disorders, cardiovascular disease, and human immunodeficiency virus infection were identified as significant risk factors for severe COVID-19 referral. Patients who received full- or booster-dose vaccinations had a lower risk of experiencing severe symptoms compared to unvaccinated patients. Notably, individuals vaccinated during the Omicron-dominant period had a substantially lower time-to-referral than those unvaccinated during the Delta-dominant period. Moreover, patients vaccinated between 1 and 6 months prior to infection had a significantly lower risk of time-to-referral than the reference group.DiscussionThese findings demonstrate early intervention in high-risk COVID-19 patients and the importance of vaccination efficacy to reduce symptom severity. The study provides valuable insights for guiding future epidemic management strategies and optimising patient care during infectious disease outbreaks.https://www.frontiersin.org/articles/10.3389/fpubh.2024.1350304/fullCOVID-19vaccinehome-isolationcommunity-isolationtime-to-referralSouthern Thailand |
| spellingShingle | Thanit Sila Thanit Sila Wisanuwee Suriyaamorn Chanavee Toh Songyos Rajborirug Smonrapat Surasombatpattana Paramee Thongsuksai Paramee Thongsuksai Chanon Kongkamol Chanon Kongkamol Sarunyou Chusri Phoomjai Sornsenee Prasit Wuthisuthimethawee Raya Chaowanawong Surasak Sangkhathat Surasak Sangkhathat Thammasin Ingviya Thammasin Ingviya Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand Frontiers in Public Health COVID-19 vaccine home-isolation community-isolation time-to-referral Southern Thailand |
| title | Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand |
| title_full | Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand |
| title_fullStr | Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand |
| title_full_unstemmed | Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand |
| title_short | Factors associated with the worsening of COVID-19 symptoms among cohorts in community- or home-isolation care in southern Thailand |
| title_sort | factors associated with the worsening of covid 19 symptoms among cohorts in community or home isolation care in southern thailand |
| topic | COVID-19 vaccine home-isolation community-isolation time-to-referral Southern Thailand |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2024.1350304/full |
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