A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal
Abstract Background Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822023227/type/journal_article |
| _version_ | 1811156352695795712 |
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| author | Víctor De la Peña-Arteaga Pedro Morgado Beatriz Couto Sónia Ferreira Inês Castro Nuno Sousa Carles Soriano-Mas Maria Picó-Pérez |
| author_facet | Víctor De la Peña-Arteaga Pedro Morgado Beatriz Couto Sónia Ferreira Inês Castro Nuno Sousa Carles Soriano-Mas Maria Picó-Pérez |
| author_sort | Víctor De la Peña-Arteaga |
| collection | DOAJ |
| description |
Abstract
Background
Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD.
Methods
Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored.
Results
Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network.
Conclusions
The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective.
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| first_indexed | 2024-04-10T04:49:01Z |
| format | Article |
| id | doaj.art-17cbba81ccf742278c2559f88e912ef7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-04-10T04:49:01Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-17cbba81ccf742278c2559f88e912ef72023-03-09T12:33:56ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-01-016510.1192/j.eurpsy.2022.2322A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisalVíctor De la Peña-Arteaga0https://orcid.org/0000-0001-8627-2653Pedro Morgado1https://orcid.org/0000-0003-3880-3258Beatriz Couto2https://orcid.org/0000-0002-3746-9959Sónia Ferreira3https://orcid.org/0000-0002-3527-1623Inês Castro4Nuno Sousa5https://orcid.org/0000-0002-8755-5126Carles Soriano-Mas6https://orcid.org/0000-0003-4574-6597Maria Picó-Pérez7https://orcid.org/0000-0002-1573-2445Psychiatry and Mental Health Group, Neuroscience Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, School of Medicine, Universitat de Barcelona – UB, L’Hospitalet de Llobregat, Barcelona, Spain Life and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal 2CA-Clinical Academic Center, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal 2CA-Clinical Academic Center, Braga, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, PortugalLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal 2CA-Clinical Academic Center, Braga, PortugalPsychiatry and Mental Health Group, Neuroscience Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain Network Center for Biomedical Research on Mental Health (CIBERSAM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain Department of Social Psychology and Quantitative Psychology, Universitat de Barcelona – UB, Barcelona, SpainLife and Health Sciences Research Institute (ICVS), School of Medicine, Universidade do Minho, Braga, Portugal ICVS/3B’s, PT Government Associate Laboratory, Braga/Guimarães, Portugal 2CA-Clinical Academic Center, Braga, Portugal Departamento de Psicología Básica, Clínica y Psicobiología, Universitat Jaume I, Castelló de la Plana, Spain Abstract Background Patients with obsessive-compulsive disorder (OCD) present difficulties in the cognitive regulation of emotions, possibly because of inefficient recruitment of distributed patterns of frontal cortex regions. The aim of the present study is to characterize the brain networks, and their dysfunctions, related to emotion regulation alterations observed during cognitive reappraisal in OCD. Methods Adult patients with OCD (n = 31) and healthy controls (HC; n = 30) were compared during performance of a functional magnetic resonance imaging cognitive reappraisal protocol. We used a free independent component analysis approach to analyze network-level alterations during emotional experience and regulation. Correlations with behavioral scores were also explored. Results Analyses were focused on six networks encompassing the frontal cortex. OCD patients showed decreased activation of the frontotemporal network in comparison with HC (F(1,58) = 7.81, p = 0.007) during cognitive reappraisal. A similar trend was observed in the left frontoparietal network. Conclusions The present study demonstrates that patients with OCD show decreased activation of specific networks implicating the frontal cortex during cognitive reappraisal. These outcomes should help to better characterize the psychological processes modulating fear, anxiety, and other core symptoms of patients with OCD, as well as the associated neurobiological alterations, from a system-level perspective. https://www.cambridge.org/core/product/identifier/S0924933822023227/type/journal_articleCognitive reappraisalemotion regulationfMRIfrontal networksOCD |
| spellingShingle | Víctor De la Peña-Arteaga Pedro Morgado Beatriz Couto Sónia Ferreira Inês Castro Nuno Sousa Carles Soriano-Mas Maria Picó-Pérez A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal European Psychiatry Cognitive reappraisal emotion regulation fMRI frontal networks OCD |
| title | A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal |
| title_full | A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal |
| title_fullStr | A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal |
| title_full_unstemmed | A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal |
| title_short | A functional magnetic resonance imaging study of frontal networks in obsessive-compulsive disorder during cognitive reappraisal |
| title_sort | functional magnetic resonance imaging study of frontal networks in obsessive compulsive disorder during cognitive reappraisal |
| topic | Cognitive reappraisal emotion regulation fMRI frontal networks OCD |
| url | https://www.cambridge.org/core/product/identifier/S0924933822023227/type/journal_article |
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