Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis
Abstract Background Both osteoporosis and cognitive impairment affect overall health in elderly individuals. This study aimed to investigate the association between cognitive impairment and the risk of osteoporosis. Methods PubMed, Web of Science, and the Cochrane Library were searched for studies o...
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | BMC Geriatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12877-023-04548-z |
| _version_ | 1797397724219310080 |
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| author | Chengxin Xie Chenglong Wang Hua Luo |
| author_facet | Chengxin Xie Chenglong Wang Hua Luo |
| author_sort | Chengxin Xie |
| collection | DOAJ |
| description | Abstract Background Both osteoporosis and cognitive impairment affect overall health in elderly individuals. This study aimed to investigate the association between cognitive impairment and the risk of osteoporosis. Methods PubMed, Web of Science, and the Cochrane Library were searched for studies on the association between osteoporosis and cognitive impairment from their inception until August 2023. The random-effects model was used to calculate the pooled risk ratio (RR) of osteoporosis in patients with cognitive impairment. Subgroup analysis was used to detect the sources of heterogeneity. Sensitivity analysis was used to test the robustness of the pooled results. Funnel plots, Egger’s test, and Begg’s test were used to test publication bias. Results Ten studies involving 9,872 patients were included in this meta-analysis. The pooled results showed that patients with cognitive impairment had an increased risk of osteoporosis (RR = 1.56, 95% confidence interval [CI]: 1.30–1.87, p < 0.001). Subgroup analysis showed that patients with Alzheimer’s disease (AD) are at 1.7-fold risk of osteoporosis compared with the control group (RR = 1.70, 95% CI: 1.23–2.37, p = 0.001), and sex, cognitive classification, study region, study design, and study quality might be the sources of heterogeneity. Sensitivity analysis showed robustness of the pooled results. No significant publication bias was found (Begg’s test, p = 0.474; Egger’s test, p = 0.065). Conclusion Current evidence suggests that patients with cognitive impairment are at increased risk of osteoporosis, especially patients with AD. |
| first_indexed | 2024-03-09T01:15:19Z |
| format | Article |
| id | doaj.art-17ce435b8fb643e3b89811221b091f57 |
| institution | Directory Open Access Journal |
| issn | 1471-2318 |
| language | English |
| last_indexed | 2024-03-09T01:15:19Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Geriatrics |
| spelling | doaj.art-17ce435b8fb643e3b89811221b091f572023-12-10T12:31:06ZengBMCBMC Geriatrics1471-23182023-12-0123111010.1186/s12877-023-04548-zIncreased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysisChengxin Xie0Chenglong Wang1Hua Luo2Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityDepartment of Orthopedics, Taizhou Central Hospital (Taizhou University Hospital)Department of Orthopedics, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityAbstract Background Both osteoporosis and cognitive impairment affect overall health in elderly individuals. This study aimed to investigate the association between cognitive impairment and the risk of osteoporosis. Methods PubMed, Web of Science, and the Cochrane Library were searched for studies on the association between osteoporosis and cognitive impairment from their inception until August 2023. The random-effects model was used to calculate the pooled risk ratio (RR) of osteoporosis in patients with cognitive impairment. Subgroup analysis was used to detect the sources of heterogeneity. Sensitivity analysis was used to test the robustness of the pooled results. Funnel plots, Egger’s test, and Begg’s test were used to test publication bias. Results Ten studies involving 9,872 patients were included in this meta-analysis. The pooled results showed that patients with cognitive impairment had an increased risk of osteoporosis (RR = 1.56, 95% confidence interval [CI]: 1.30–1.87, p < 0.001). Subgroup analysis showed that patients with Alzheimer’s disease (AD) are at 1.7-fold risk of osteoporosis compared with the control group (RR = 1.70, 95% CI: 1.23–2.37, p = 0.001), and sex, cognitive classification, study region, study design, and study quality might be the sources of heterogeneity. Sensitivity analysis showed robustness of the pooled results. No significant publication bias was found (Begg’s test, p = 0.474; Egger’s test, p = 0.065). Conclusion Current evidence suggests that patients with cognitive impairment are at increased risk of osteoporosis, especially patients with AD.https://doi.org/10.1186/s12877-023-04548-zOsteoporosisBone lossCognitive impairmentAlzheimer’s diseaseDementiaMeta-analysis |
| spellingShingle | Chengxin Xie Chenglong Wang Hua Luo Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis BMC Geriatrics Osteoporosis Bone loss Cognitive impairment Alzheimer’s disease Dementia Meta-analysis |
| title | Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis |
| title_full | Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis |
| title_fullStr | Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis |
| title_full_unstemmed | Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis |
| title_short | Increased risk of osteoporosis in patients with cognitive impairment: a systematic review and meta-analysis |
| title_sort | increased risk of osteoporosis in patients with cognitive impairment a systematic review and meta analysis |
| topic | Osteoporosis Bone loss Cognitive impairment Alzheimer’s disease Dementia Meta-analysis |
| url | https://doi.org/10.1186/s12877-023-04548-z |
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