Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases

Successful case of olaparib treatment for castration-resistant prostate cancer with multiple DNA repair gene mutations: Use of comprehensive genome profiling for treatment-refractory cases

Herein, we report a case of a 59-year-old man with advanced castration-resistant prostate cancer with rectal invasion. Multimodal treatment, including drug therapy, surgery, and radiation therapy was sequentially performed; however, lymph node metastases repeatedly occurred. Tumor genomic profiling...

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Bibliographic Details
Main Authors: Yukiyoshi Hirayama, Minoru Kato, Kaoru Kimura, Taiyo Otoshi, Takeshi Yamasaki, Junji Uchida
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Urology Case Reports
Subjects:
Castration-resistant prostate cancer
DNA repair
Poly ADP-ribose polymerase inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2214442022002224

Internet

http://www.sciencedirect.com/science/article/pii/S2214442022002224

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