| Summary: | Respiratory disorders are the most common cause for higher morbidity and mortality rate in India. Higher oxygen concentration of extrauterine existence causes increased erythrocyte lysis lead to release of iron in neonates. Iron is known to catalyze the formation of Reactive oxygen species. Involvement of hemoglobin and iron in oxygen-mediated reactions stimulate us to study the role of these in neonates.Objectives :i)To estimate the concentration of Haemoglobin, serum iron, serum lipid peroxidation in neonates with respiratory disorders; and compare those with that of healthy controls. ii)To study the role of these parameters in neonates with respiratory disorders.Materials and Methods: Present study includes 50 neonates suffering from respiratory disorders and 50 healthy neonates as controls. Samples collected from these were used for the estimation of haemoglobin, serum iron, and serum lipid peroxidation.Observations: Significantly (p<0.001) increased levels of serum iron and lipid peroxidation were observed in neonates with respiratory disorders when compared those with control values. These levels were found significantly (p<0.001) higher in preterm than full-term neonates. Concentration of haemoglobin showed no significant difference in both groups.Conclusion: Exacerbation of oxidative stress in neonates with respiratory disorders may be due to hypoxia induced free radical generation, higher oxidative tendency of HbF and elevated iron. Premature neonates are probably unprepared for extra uterine life in an oxygen rich environment and due to this they are more prone to oxidative insult. Thus this study reveals the pro-oxidant role of HbF and iron, which enhances the oxidative stress in respiratory disorder.
|
|---|