Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders
The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral component of the g...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996123000499 |
| _version_ | 1797867365598232576 |
|---|---|
| author | Shasha Peng Jiachen Liu Chuntian Liang Lijun Yang Gaiqing Wang |
| author_facet | Shasha Peng Jiachen Liu Chuntian Liang Lijun Yang Gaiqing Wang |
| author_sort | Shasha Peng |
| collection | DOAJ |
| description | The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral component of the glymphatic system. In recent years, many studies have shown that AQP4 affects the morbidity and recovery process of CNS disorders through the glymphatic system, and AQP4 shows notable variability in CNS disorders and is part of the pathogenesis of these diseases. Therefore, there has been considerable interest in AQP4 as a potential and promising target for regulating and improving neurological impairment. This review aims to summarize the pathophysiological role that AQP4 plays in several CNS disorders by affecting the clearance function of the glymphatic system. The findings can contribute to a better understanding of the self-regulatory functions in CNS disorders that AQP4 were involved in and provide new therapeutic alternatives for incurable debilitating neurodegenerative disorders of CNS in the future. |
| first_indexed | 2024-04-09T23:40:08Z |
| format | Article |
| id | doaj.art-17d338d9d82b4be29452987638cc518f |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-04-09T23:40:08Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-17d338d9d82b4be29452987638cc518f2023-03-19T04:37:05ZengElsevierNeurobiology of Disease1095-953X2023-04-01179106035Aquaporin-4 in glymphatic system, and its implication for central nervous system disordersShasha Peng0Jiachen Liu1Chuntian Liang2Lijun Yang3Gaiqing Wang456 Xinjian southern St, Department of Pharmacology, School of Basical Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China172 Tongzipo Rd, Xiangya Medical College of Central South University, Changsha, Hunan 410013, China56 Xinjian southern St, Department of Neurology, Shanxi Medical University, Taiyuan, Shanxi 030001, China56 Xinjian southern St, Department of Pharmacology, School of Basical Medical Sciences, Shanxi Medical University, Taiyuan, Shanxi 030001, China56 Xinjian southern St, Department of Neurology, Shanxi Medical University, Taiyuan, Shanxi 030001, China; 146 JieFang forth Rd, Department of Neurology, SanYa Central Hospital (Hainan Third People's Hospital), Hainan Medical University, SanYa, Hainan 572000, China; Corresponding author at: 146 JieFang forth Rd, Department of Neurology, SanYa Central Hospital (Hainan Third People's Hospital), Hainan Medical University, SanYa, Hainan 572000, China.The clearance function is essential for maintaining brain tissue homeostasis, and the glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 (AQP4) is the most abundantly expressed aquaporin in the central nervous system (CNS) and is an integral component of the glymphatic system. In recent years, many studies have shown that AQP4 affects the morbidity and recovery process of CNS disorders through the glymphatic system, and AQP4 shows notable variability in CNS disorders and is part of the pathogenesis of these diseases. Therefore, there has been considerable interest in AQP4 as a potential and promising target for regulating and improving neurological impairment. This review aims to summarize the pathophysiological role that AQP4 plays in several CNS disorders by affecting the clearance function of the glymphatic system. The findings can contribute to a better understanding of the self-regulatory functions in CNS disorders that AQP4 were involved in and provide new therapeutic alternatives for incurable debilitating neurodegenerative disorders of CNS in the future.http://www.sciencedirect.com/science/article/pii/S0969996123000499Aquaporin 4Glymphatic systemCentral nervous systemIntracerebral hemorrhageAlzheimer's diseaseTraumatic brain injury |
| spellingShingle | Shasha Peng Jiachen Liu Chuntian Liang Lijun Yang Gaiqing Wang Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders Neurobiology of Disease Aquaporin 4 Glymphatic system Central nervous system Intracerebral hemorrhage Alzheimer's disease Traumatic brain injury |
| title | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders |
| title_full | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders |
| title_fullStr | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders |
| title_full_unstemmed | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders |
| title_short | Aquaporin-4 in glymphatic system, and its implication for central nervous system disorders |
| title_sort | aquaporin 4 in glymphatic system and its implication for central nervous system disorders |
| topic | Aquaporin 4 Glymphatic system Central nervous system Intracerebral hemorrhage Alzheimer's disease Traumatic brain injury |
| url | http://www.sciencedirect.com/science/article/pii/S0969996123000499 |
| work_keys_str_mv | AT shashapeng aquaporin4inglymphaticsystemanditsimplicationforcentralnervoussystemdisorders AT jiachenliu aquaporin4inglymphaticsystemanditsimplicationforcentralnervoussystemdisorders AT chuntianliang aquaporin4inglymphaticsystemanditsimplicationforcentralnervoussystemdisorders AT lijunyang aquaporin4inglymphaticsystemanditsimplicationforcentralnervoussystemdisorders AT gaiqingwang aquaporin4inglymphaticsystemanditsimplicationforcentralnervoussystemdisorders |