Identification of a Novel Therapeutic Target against XDR <i>Salmonella</i> Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening

Identification of a Novel Therapeutic Target against XDR <i>Salmonella</i> Typhi H58 Using Genomics Driven Approach Followed Up by Natural Products Virtual Screening

Typhoid fever is caused by a pathogenic, rod-shaped, flagellated, and Gram-negative bacterium known as <i>Salmonella</i> Typhi. It features a polysaccharide capsule that acts as a virulence factor and deceives the host immune system by protecting phagocytosis. Typhoid fever remains a maj...

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Bibliographic Details
Main Authors: Khurshid Jalal, Kanwal Khan, Muhammad Hassam, Muhammad Naseer Abbas, Reaz Uddin, Ameer Khusro, Muhammad Umar Khayam Sahibzada, Márió Gajdács
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Microorganisms
Subjects:
<i>Salmonella</i> Typhi H58
subtractive genomic analysis
typhoid fever
drug targets
functional annotation
XDR
Online Access:https://www.mdpi.com/2076-2607/9/12/2512

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