No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women
Background: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women. Methods: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure we...
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2019-08-01
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Online Access: | https://www.mdpi.com/2072-6643/11/9/1976 |
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author | Małgorzata Jamka Patrycja Krzyżanowska-Jankowska Edyta Mądry Aleksandra Lisowska Paweł Bogdański Jarosław Walkowiak |
author_facet | Małgorzata Jamka Patrycja Krzyżanowska-Jankowska Edyta Mądry Aleksandra Lisowska Paweł Bogdański Jarosław Walkowiak |
author_sort | Małgorzata Jamka |
collection | DOAJ |
description | Background: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women. Methods: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure were measured. Body mass index (BMI) was calculated. Fat mass and visceral adipose tissue mass were assessed using dual X-ray absorptiometry scan. Fasting glucose, insulin, lipid profile, high sensitivity C-reactive protein (hs-CRP) and lactoferrin levels were determined. Results: Lactoferrin levels did not differ between MHO and MUHO subjects (median (interquartile range): 1639 (1055−2396) vs. 1622 (1009−23345) ng/mL). However, in the total population insulin (r = 0.131, <i>p</i> = 0.0234) and hs-CRP (r = 0.165, <i>p</i> = 0.0045) levels were correlated with lactoferrin concentrations. In addition, a weak positive association between serum lactoferrin concentrations and anthropometric parameters was also detected, and predominantly referred to MHO group (body weight: r = 0.231, <i>p</i> = 0.0201; BMI: r = 0.286, <i>p</i> = 0.0037; waist circumference: r = 0.258, <i>p</i> = 0.0092). In addition, serum lactoferrin concentrations were negatively correlated with fasting glucose (r = −0.250, <i>p</i> = 0.0115) and HDL-C levels (r = −0.203, <i>p</i> = 0.0411) in MHO subjects. Conclusions: Lactoferrin levels did not differ between MHO and MUHO women. However, some mild correlations between lactoferrin concentrations and anthropometric and metabolic parameters were observed mostly in MHO subjects. |
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spelling | doaj.art-17d8f42ea60a4cdba89e52ed59d053bb2022-12-22T02:41:39ZengMDPI AGNutrients2072-66432019-08-01119197610.3390/nu11091976nu11091976No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese WomenMałgorzata Jamka0Patrycja Krzyżanowska-Jankowska1Edyta Mądry2Aleksandra Lisowska3Paweł Bogdański4Jarosław Walkowiak5Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Physiology, Poznan University of Medical Sciences, Święcickiego Str. 6, 60-781 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandDepartment of Treatment of Obesity, Metabolic Disorders and Clinical Dietetics, Poznan University of Medical Sciences, Szamarzewskiego Str. 84, 60-569 Poznań, PolandDepartment of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Szpitalna Str. 27/33, 60-572 Poznań, PolandBackground: The aim of the study was to compare serum lactoferrin concentrations in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) women. Methods: Three hundred (101 MHO and 199 MUHO) women were recruited to the study. Basic anthropometric parameters and blood pressure were measured. Body mass index (BMI) was calculated. Fat mass and visceral adipose tissue mass were assessed using dual X-ray absorptiometry scan. Fasting glucose, insulin, lipid profile, high sensitivity C-reactive protein (hs-CRP) and lactoferrin levels were determined. Results: Lactoferrin levels did not differ between MHO and MUHO subjects (median (interquartile range): 1639 (1055−2396) vs. 1622 (1009−23345) ng/mL). However, in the total population insulin (r = 0.131, <i>p</i> = 0.0234) and hs-CRP (r = 0.165, <i>p</i> = 0.0045) levels were correlated with lactoferrin concentrations. In addition, a weak positive association between serum lactoferrin concentrations and anthropometric parameters was also detected, and predominantly referred to MHO group (body weight: r = 0.231, <i>p</i> = 0.0201; BMI: r = 0.286, <i>p</i> = 0.0037; waist circumference: r = 0.258, <i>p</i> = 0.0092). In addition, serum lactoferrin concentrations were negatively correlated with fasting glucose (r = −0.250, <i>p</i> = 0.0115) and HDL-C levels (r = −0.203, <i>p</i> = 0.0411) in MHO subjects. Conclusions: Lactoferrin levels did not differ between MHO and MUHO women. However, some mild correlations between lactoferrin concentrations and anthropometric and metabolic parameters were observed mostly in MHO subjects.https://www.mdpi.com/2072-6643/11/9/1976lactoferrinmetabolically healthy obesitymetabolically unhealthy obesitymetabolic syndromeobesity |
spellingShingle | Małgorzata Jamka Patrycja Krzyżanowska-Jankowska Edyta Mądry Aleksandra Lisowska Paweł Bogdański Jarosław Walkowiak No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women Nutrients lactoferrin metabolically healthy obesity metabolically unhealthy obesity metabolic syndrome obesity |
title | No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women |
title_full | No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women |
title_fullStr | No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women |
title_full_unstemmed | No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women |
title_short | No Difference in Lactoferrin Levels between Metabolically Healthy and Unhealthy Obese Women |
title_sort | no difference in lactoferrin levels between metabolically healthy and unhealthy obese women |
topic | lactoferrin metabolically healthy obesity metabolically unhealthy obesity metabolic syndrome obesity |
url | https://www.mdpi.com/2072-6643/11/9/1976 |
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