Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing

Alzheimer's disease (AD) is a neurodegenerative disease that causes progressive loss of cognitive functions, leading to dementia. Two types of lesions are found in AD brains: neurofibrillary tangles and senile plaques. The latter are composed mainly of the β‐amyloid peptide (Aβ) generated by am...

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Bibliographic Details
Main Authors: Marie Decock, Laetitia El Haylani, Serena Stanga, Ilse Dewachter, Jean-Noël Octave, Steven O. Smith, Stefan N. Constantinescu, Pascal Kienlen-Campard
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:FEBS Open Bio
Subjects:
Alzheimer disease
APP
Dimerization
GXXXG motifs
Amyloid beta peptide
Split luciferase
Online Access:https://doi.org/10.1016/j.fob.2015.09.002

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