The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.
<h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical charac...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0250986 |
| _version_ | 1818436178001526784 |
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| author | Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon |
| author_facet | Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon |
| author_sort | Yoon Jin Cha |
| collection | DOAJ |
| description | <h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical characteristics and survival outcome according to YAP1 and TP53 mutation have been poorly identified in breast cancer.<h4>Patients and methods</h4>Retrospectively, 533 breast tumor tissues were collected at the Seoul St Mary's hospital and Gangnam Severance Hospital from 1992 to 2017. Immunohistochemistry with YAP1 and p53 specific antibodies were performed, and the clinical data were analyzed.<h4>Results</h4>Mutant p53 pattern was associated with aggressive tumor features and advanced anatomical stage. Inferior overall survival (OS) and recurrence free survival (RFS) were related with mutant p53 pattern cases with low nuclear YAP1 expression (P = 0.0009 and P = 0.0011, respectively). Multivariate analysis showed that mutant p53 pattern was an independent prognostic marker for OS [hazard ratios (HR): 2.938, 95% confidence intervals (CIs): 1.028-8.395, P = 0.044] and RFS (HR: 1.842, 95% CIs: 1.026-3.304). However, in cases with high nuclear YAP1 expression, there were no significantly difference in OS and RFS according to p53 staining pattern.<h4>Conclusion</h4>We found that mutant p53 pattern is a poor prognostic biomarker in breast tumor with low nuclear YAP1 expression. Our findings suggest that interaction between nuclear YAP1 and p53 expression pattern impact survival outcomes. |
| first_indexed | 2024-12-14T17:04:38Z |
| format | Article |
| id | doaj.art-17de6630c8b04eb7ad5fe3cea0909380 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T17:04:38Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-17de6630c8b04eb7ad5fe3cea09093802022-12-21T22:53:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01165e025098610.1371/journal.pone.0250986The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients.Yoon Jin ChaDooreh KimSoong June BaeSung Gwe AhnJoon JeongMin Kyung ChoPill Sun PaikTae-Kyung YooWoo-Chan ParkChang Ik Yoon<h4>Background</h4>Yes-associated protein 1 (YAP1) is a key effector molecule regulated by the Hippo pathway and described as a poor prognostic factor in breast cancer. Tumor protein 53 (TP53) mutation is well known as a biomarker related to poor survival outcomes. So far clinical characteristics and survival outcome according to YAP1 and TP53 mutation have been poorly identified in breast cancer.<h4>Patients and methods</h4>Retrospectively, 533 breast tumor tissues were collected at the Seoul St Mary's hospital and Gangnam Severance Hospital from 1992 to 2017. Immunohistochemistry with YAP1 and p53 specific antibodies were performed, and the clinical data were analyzed.<h4>Results</h4>Mutant p53 pattern was associated with aggressive tumor features and advanced anatomical stage. Inferior overall survival (OS) and recurrence free survival (RFS) were related with mutant p53 pattern cases with low nuclear YAP1 expression (P = 0.0009 and P = 0.0011, respectively). Multivariate analysis showed that mutant p53 pattern was an independent prognostic marker for OS [hazard ratios (HR): 2.938, 95% confidence intervals (CIs): 1.028-8.395, P = 0.044] and RFS (HR: 1.842, 95% CIs: 1.026-3.304). However, in cases with high nuclear YAP1 expression, there were no significantly difference in OS and RFS according to p53 staining pattern.<h4>Conclusion</h4>We found that mutant p53 pattern is a poor prognostic biomarker in breast tumor with low nuclear YAP1 expression. Our findings suggest that interaction between nuclear YAP1 and p53 expression pattern impact survival outcomes.https://doi.org/10.1371/journal.pone.0250986 |
| spellingShingle | Yoon Jin Cha Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Min Kyung Cho Pill Sun Paik Tae-Kyung Yoo Woo-Chan Park Chang Ik Yoon The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. PLoS ONE |
| title | The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. |
| title_full | The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. |
| title_fullStr | The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. |
| title_full_unstemmed | The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. |
| title_short | The association between the expression of nuclear Yes-associated protein 1 (YAP1) and p53 protein expression profile in breast cancer patients. |
| title_sort | association between the expression of nuclear yes associated protein 1 yap1 and p53 protein expression profile in breast cancer patients |
| url | https://doi.org/10.1371/journal.pone.0250986 |
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