The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer

The Role of Somatic Mutations on the Immune Response of the Tumor Microenvironment in Prostate Cancer

Immunotherapy has improved patient survival in many types of cancer, but for prostate cancer, initial results with immunotherapy have been disappointing. Prostate cancer is considered an immunologically excluded or cold tumor, unable to generate an effective T-cell response against cancer cells. How...

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Bibliographic Details
Main Authors: Camila Morais Melo, Thiago Vidotto, Luiz Paulo Chaves, William Lautert-Dutra, Rodolfo Borges dos Reis, Jeremy Andrew Squire
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
immunotherapy
checkpoint blockade
immune evasion
innate and adaptive immune system
oncogenes
tumor suppressor genes
Online Access:https://www.mdpi.com/1422-0067/22/17/9550

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