Development of lactobionic acid conjugated-copper chelators as anticancer candidates for hepatocellular carcinoma

Development of lactobionic acid conjugated-copper chelators as anticancer candidates for hepatocellular carcinoma

Hepatic copper deposition leads to metabolic disorders, rapid increase in reactive oxygen species (ROS) levels, and even the occurrence and metastasis of hepatocellular carcinoma. Copper chelation or copper transporter inhibition have already been developed into an effective method to control the ca...

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Bibliographic Details
Main Authors: Xueke Zhao, Xiang Li, Xiaoping Huang, Shuyu Liang, Penggen Cai, Yuhui Wang, Yongming Cui, Wu Chen, Xiongwei Dong
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Arabian Journal of Chemistry
Subjects:
Copper chelation
Hepatocellular carcinoma
Copper deposition
Apoptosis
Hepatic targeting
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221002562

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