PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain
The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-25416-7 |
| _version_ | 1818403650064613376 |
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| author | Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang |
| author_facet | Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang |
| author_sort | Maorong Wen |
| collection | DOAJ |
| description | The cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels. |
| first_indexed | 2024-12-14T08:27:37Z |
| format | Article |
| id | doaj.art-17e35fdce2dc46e3ae4946ce57c81587 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:27:37Z |
| publishDate | 2021-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-17e35fdce2dc46e3ae4946ce57c815872022-12-21T23:09:35ZengNature PortfolioNature Communications2041-17232021-08-0112111310.1038/s41467-021-25416-7PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domainMaorong Wen0Yunlei Cao1Bin Wu2Taoran Xiao3Ruiyu Cao4Qian Wang5Xiwei Liu6Hongjuan Xue7Yang Yu8Jialing Lin9Chenqi Xu10Jie Xu11Bo OuYang12State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesNational Facility for Protein Science in Shanghai, ZhangJiang lab, Shanghai Advanced Research Institute, Chinese Academy of SciencesDepartment of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences CenterState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesInstitutes of Biomedical Sciences, Fudan UniversityState Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of SciencesThe cytoplasmic domain of PD-L1 (PD-L1-CD) is involved in regulating PD-L1 stability and degradation. Here the authors show that membrane binding of PD-L1-CD mediates the cellular levels of PD-L1, while metformin can disrupt the interaction between PD-L1-CD and the membrane to reduce PD-L1 levels.https://doi.org/10.1038/s41467-021-25416-7 |
| spellingShingle | Maorong Wen Yunlei Cao Bin Wu Taoran Xiao Ruiyu Cao Qian Wang Xiwei Liu Hongjuan Xue Yang Yu Jialing Lin Chenqi Xu Jie Xu Bo OuYang PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain Nature Communications |
| title | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| title_full | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| title_fullStr | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| title_full_unstemmed | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| title_short | PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| title_sort | pd l1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain |
| url | https://doi.org/10.1038/s41467-021-25416-7 |
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