HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report
Abstract Background Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child wh...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Pediatrics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12887-021-03100-5 |
| _version_ | 1818750310021070848 |
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| author | Wei Hu Xiao-hong Yu Wei-qin Wei Xuan Xiang |
| author_facet | Wei Hu Xiao-hong Yu Wei-qin Wei Xuan Xiang |
| author_sort | Wei Hu |
| collection | DOAJ |
| description | Abstract Background Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a girl from China. Her special clinical manifestations and laboratory diagnosis results can provide clinicians with the basis for diagnosis and treatment of T.marneffei related rare diseases. Case presntation We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child’s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later. Conclusion This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children. |
| first_indexed | 2024-12-18T04:17:38Z |
| format | Article |
| id | doaj.art-17e394bb06c140fc8cbad683c66698fe |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-12-18T04:17:38Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-17e394bb06c140fc8cbad683c66698fe2022-12-21T21:21:19ZengBMCBMC Pediatrics1471-24312022-01-012211610.1186/s12887-021-03100-5HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case reportWei Hu0Xiao-hong Yu1Wei-qin Wei2Xuan Xiang3Emergency department, Guiyang Second People’s HospitalEmergency department, Guiyang Second People’s HospitalEmergency department, Affiliated Hospital of Guizhou Medical UniversityEmergency department, Guiyang Second People’s HospitalAbstract Background Talaromyces Marneffei (Penicillium marneffei, T.marneffei) has been frequently reported in patients with adult acquired immunodeficiency syndrome. Still, cases of children with HIV combined with T.marneffei infection are very rare. This report describes the case of a HIV-child who is a girl from China. Her special clinical manifestations and laboratory diagnosis results can provide clinicians with the basis for diagnosis and treatment of T.marneffei related rare diseases. Case presntation We reported a single case of 7-year-old Chinese female patient who presented with fever, abdominal pain, multiple lymphadenopathy, hepatosplenomegaly, left lower extremity ecchymosis, and bloody stool. The patient received anti-inflammatory therapy; however, her symptoms did not improve. Consequently, she was diagnosed with T.marneffei and HIV infection; it was also confirmed that her mother did not undergo HIV blocking therapy during pregnancy. Yet, the child’s family refused all treatment, after which the child was discharged from the hospital. The patient died a few days later. Conclusion This case suggested that children with AIDS suffering from fever, lymphadenopathy and coagulation dysfunction, penicilliosis should be suspected. Clinicians should diagnose the disease early through laboratory and imaging results, which can help reduce the mortality, prolong the survival time and improve the quality of life of children.https://doi.org/10.1186/s12887-021-03100-5HIV-childPenicilliosisTalaromyces marneffeiAIDSSmear analysisRare disease |
| spellingShingle | Wei Hu Xiao-hong Yu Wei-qin Wei Xuan Xiang HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report BMC Pediatrics HIV-child Penicilliosis Talaromyces marneffei AIDS Smear analysis Rare disease |
| title | HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report |
| title_full | HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report |
| title_fullStr | HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report |
| title_full_unstemmed | HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report |
| title_short | HIV-child with disseminated Talaromyces Marneffei (Penicillium marneffei) infection: a rare severe case report |
| title_sort | hiv child with disseminated talaromyces marneffei penicillium marneffei infection a rare severe case report |
| topic | HIV-child Penicilliosis Talaromyces marneffei AIDS Smear analysis Rare disease |
| url | https://doi.org/10.1186/s12887-021-03100-5 |
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