The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders
Diabetes-induced vascular disorder is considered one of the deadly risk factors among diabetic patients that are caused by persistent hyperglycemia that eventually leads to cardiovascular diseases. Elevated reactive oxygen species (ROS) due to high blood glucose levels activate signaling pathways su...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-06-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/12/6396 |
| _version_ | 1797486613234712576 |
|---|---|
| author | Nor Anizah Mohd Nor Siti Balkis Budin Satirah Zainalabidin Juriyati Jalil Syaifuzah Sapian Fatin Farhana Jubaidi Nur Najmi Mohamad Anuar |
| author_facet | Nor Anizah Mohd Nor Siti Balkis Budin Satirah Zainalabidin Juriyati Jalil Syaifuzah Sapian Fatin Farhana Jubaidi Nur Najmi Mohamad Anuar |
| author_sort | Nor Anizah Mohd Nor |
| collection | DOAJ |
| description | Diabetes-induced vascular disorder is considered one of the deadly risk factors among diabetic patients that are caused by persistent hyperglycemia that eventually leads to cardiovascular diseases. Elevated reactive oxygen species (ROS) due to high blood glucose levels activate signaling pathways such as AGE/RAGE, PKC, polyol, and hexosamine pathways. The activated signaling pathway triggers oxidative stress, inflammation, and apoptosis which later lead to vascular dysfunction induced by diabetes. Polyphenol is a bioactive compound that can be found abundantly in plants such as vegetables, fruits, whole grains, and nuts. This compound exerts therapeutic effects in alleviating diabetes-induced vascular disorder, mainly due to its potential as an anti-oxidative, anti-inflammatory, and anti-apoptotic agent. In this review, we sought to summarize the recent discovery of polyphenol treatments in modulating associated genes involved in the progression of diabetes-induced vascular disorder. |
| first_indexed | 2024-03-09T23:36:43Z |
| format | Article |
| id | doaj.art-17e69c6f0278440880b1b46242f0e314 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T23:36:43Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-17e69c6f0278440880b1b46242f0e3142023-11-23T16:59:55ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012312639610.3390/ijms23126396The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular DisordersNor Anizah Mohd Nor0Siti Balkis Budin1Satirah Zainalabidin2Juriyati Jalil3Syaifuzah Sapian4Fatin Farhana Jubaidi5Nur Najmi Mohamad Anuar6Centre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaProgramme of Biomedical Science, Centre for Toxicology and Health Risk Research, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCenter for Drug and Herbal Development, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaCentre for Diagnostic, Therapeutic and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaProgramme of Biomedical Science, Centre for Toxicology and Health Risk Research, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, MalaysiaDiabetes-induced vascular disorder is considered one of the deadly risk factors among diabetic patients that are caused by persistent hyperglycemia that eventually leads to cardiovascular diseases. Elevated reactive oxygen species (ROS) due to high blood glucose levels activate signaling pathways such as AGE/RAGE, PKC, polyol, and hexosamine pathways. The activated signaling pathway triggers oxidative stress, inflammation, and apoptosis which later lead to vascular dysfunction induced by diabetes. Polyphenol is a bioactive compound that can be found abundantly in plants such as vegetables, fruits, whole grains, and nuts. This compound exerts therapeutic effects in alleviating diabetes-induced vascular disorder, mainly due to its potential as an anti-oxidative, anti-inflammatory, and anti-apoptotic agent. In this review, we sought to summarize the recent discovery of polyphenol treatments in modulating associated genes involved in the progression of diabetes-induced vascular disorder.https://www.mdpi.com/1422-0067/23/12/6396oxidative stressinflammationapoptosisphenolic acidflavonoidstilbene |
| spellingShingle | Nor Anizah Mohd Nor Siti Balkis Budin Satirah Zainalabidin Juriyati Jalil Syaifuzah Sapian Fatin Farhana Jubaidi Nur Najmi Mohamad Anuar The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders International Journal of Molecular Sciences oxidative stress inflammation apoptosis phenolic acid flavonoid stilbene |
| title | The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders |
| title_full | The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders |
| title_fullStr | The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders |
| title_full_unstemmed | The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders |
| title_short | The Role of Polyphenol in Modulating Associated Genes in Diabetes-Induced Vascular Disorders |
| title_sort | role of polyphenol in modulating associated genes in diabetes induced vascular disorders |
| topic | oxidative stress inflammation apoptosis phenolic acid flavonoid stilbene |
| url | https://www.mdpi.com/1422-0067/23/12/6396 |
| work_keys_str_mv | AT noranizahmohdnor theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT sitibalkisbudin theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT satirahzainalabidin theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT juriyatijalil theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT syaifuzahsapian theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT fatinfarhanajubaidi theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT nurnajmimohamadanuar theroleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT noranizahmohdnor roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT sitibalkisbudin roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT satirahzainalabidin roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT juriyatijalil roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT syaifuzahsapian roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT fatinfarhanajubaidi roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders AT nurnajmimohamadanuar roleofpolyphenolinmodulatingassociatedgenesindiabetesinducedvasculardisorders |