A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance
BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes. OBJECTIVE: This study aimed to determine the...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-08-01
|
| Series: | AJOG Global Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666577821000113 |
| _version_ | 1818600063647088640 |
|---|---|
| author | Manoj Mohan, MRCOG Sanjay Swargathmadhom Prabhu, MRCOG Abdul Kareem Pullattayil, MSIt Stephen Lindow, FRCOG |
| author_facet | Manoj Mohan, MRCOG Sanjay Swargathmadhom Prabhu, MRCOG Abdul Kareem Pullattayil, MSIt Stephen Lindow, FRCOG |
| author_sort | Manoj Mohan, MRCOG |
| collection | DOAJ |
| description | BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes. OBJECTIVE: This study aimed to determine the prevalence of gestational diabetes in women with obstetrical cholestasis. STUDY DESIGN: A predefined protocol with a literature search was used to obtain all possible articles. A systematic review and meta-analysis of observational studies with quantifiable data published since 2010 were performed. Articles were evaluated and included in the study with specified criteria for the risk of bias using the Newcastle-Ottawa Scale. A meta-analysis was performed using Meta-analysis of Observational Studies in Epidemiology specifications to determine the prevalence of gestational diabetes in women with obstetrical cholestasis. RESULTS: A total of 16,748 patients with obstetrical cholestasis from 21 studies were included. The prevalence of gestational diabetes in women with obstetrical cholestasis was 13.9% (20 studies analyzed). Gestational diabetes was more common in women with obstetrical cholestasis than in women without obstetrical cholestasis (odds ratio, 2.129; 95% confidence interval, 1.697–2.670;10 studies). Gestational diabetes is twice more common in women with severe cholestasis than in women with mild cholestasis (odds ratio, 2.168; 95% confidence interval, 1.429–3.289; 4 studies). CONCLUSION: There is an increase in the prevalence of gestational diabetes among women diagnosed with obstetrical cholestasis. Compared with women with mild cholestasis, the increased risk of gestational diabetes in women with severe cholestatis is more than doubled. This suggests that the 2 conditions may have some biological similarities that affect clinical outcomes. |
| first_indexed | 2024-12-16T12:29:32Z |
| format | Article |
| id | doaj.art-17e9e29facaf4b91b549da9af4efa46d |
| institution | Directory Open Access Journal |
| issn | 2666-5778 |
| language | English |
| last_indexed | 2024-12-16T12:29:32Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | AJOG Global Reports |
| spelling | doaj.art-17e9e29facaf4b91b549da9af4efa46d2022-12-21T22:31:44ZengElsevierAJOG Global Reports2666-57782021-08-0113100013A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a GlanceManoj Mohan, MRCOG0Sanjay Swargathmadhom Prabhu, MRCOG1Abdul Kareem Pullattayil, MSIt2Stephen Lindow, FRCOG3Department of Obstetrics and Gynecology, Aster DM Healthcare, Doha, Qatar (Dr Mohan); Corresponding author: Manoj Mohan, MRCOG.Department of Obstetrics and Gynecology, Sidra Medicine, Doha, Qatar (Dr Prabhu)Sidra Medicine, Doha, Qatar (Mr Pullattayil)Department of Obstetrics and Gynaecology, Coombe Women and Infants University Hospital, Dublin, Ireland (Dr Lindow)BACKGROUND: Gestational diabetes and obstetrical cholestasis are common clinical conditions seen in clinical practice. There is evidence suggesting a coexisting relationship that could have a potential clinical implication related to stillbirth outcomes. OBJECTIVE: This study aimed to determine the prevalence of gestational diabetes in women with obstetrical cholestasis. STUDY DESIGN: A predefined protocol with a literature search was used to obtain all possible articles. A systematic review and meta-analysis of observational studies with quantifiable data published since 2010 were performed. Articles were evaluated and included in the study with specified criteria for the risk of bias using the Newcastle-Ottawa Scale. A meta-analysis was performed using Meta-analysis of Observational Studies in Epidemiology specifications to determine the prevalence of gestational diabetes in women with obstetrical cholestasis. RESULTS: A total of 16,748 patients with obstetrical cholestasis from 21 studies were included. The prevalence of gestational diabetes in women with obstetrical cholestasis was 13.9% (20 studies analyzed). Gestational diabetes was more common in women with obstetrical cholestasis than in women without obstetrical cholestasis (odds ratio, 2.129; 95% confidence interval, 1.697–2.670;10 studies). Gestational diabetes is twice more common in women with severe cholestasis than in women with mild cholestasis (odds ratio, 2.168; 95% confidence interval, 1.429–3.289; 4 studies). CONCLUSION: There is an increase in the prevalence of gestational diabetes among women diagnosed with obstetrical cholestasis. Compared with women with mild cholestasis, the increased risk of gestational diabetes in women with severe cholestatis is more than doubled. This suggests that the 2 conditions may have some biological similarities that affect clinical outcomes.http://www.sciencedirect.com/science/article/pii/S2666577821000113gestational diabetesmeta-analysisobstetrical cholestasis |
| spellingShingle | Manoj Mohan, MRCOG Sanjay Swargathmadhom Prabhu, MRCOG Abdul Kareem Pullattayil, MSIt Stephen Lindow, FRCOG A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance AJOG Global Reports gestational diabetes meta-analysis obstetrical cholestasis |
| title | A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance |
| title_full | A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance |
| title_fullStr | A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance |
| title_full_unstemmed | A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance |
| title_short | A meta-analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisAJOG Global Reports at a Glance |
| title_sort | meta analysis of the prevalence of gestational diabetes in patients diagnosed with obstetrical cholestasisajog global reports at a glance |
| topic | gestational diabetes meta-analysis obstetrical cholestasis |
| url | http://www.sciencedirect.com/science/article/pii/S2666577821000113 |
| work_keys_str_mv | AT manojmohanmrcog ametaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT sanjayswargathmadhomprabhumrcog ametaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT abdulkareempullattayilmsit ametaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT stephenlindowfrcog ametaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT manojmohanmrcog metaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT sanjayswargathmadhomprabhumrcog metaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT abdulkareempullattayilmsit metaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance AT stephenlindowfrcog metaanalysisoftheprevalenceofgestationaldiabetesinpatientsdiagnosedwithobstetricalcholestasisajogglobalreportsataglance |