Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations
Computational models are valuable tools for studying tissue-level mechanisms of traumatic brain injury, but to produce more accurate estimates of tissue deformation, these models must be validated against experimental data. In this study, we present in situ measurements of brain–skull displacement i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fbioe.2018.00016/full |
| _version_ | 1818204071648034816 |
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| author | Stephanie A. Pasquesi Susan S. Margulies |
| author_facet | Stephanie A. Pasquesi Susan S. Margulies |
| author_sort | Stephanie A. Pasquesi |
| collection | DOAJ |
| description | Computational models are valuable tools for studying tissue-level mechanisms of traumatic brain injury, but to produce more accurate estimates of tissue deformation, these models must be validated against experimental data. In this study, we present in situ measurements of brain–skull displacement in the neonatal piglet head (n = 3) at the sagittal midline during six rapid non-impact rotations (two rotations per specimen) with peak angular velocities averaging 51.7 ± 1.4 rad/s. Marks on the sagittally cut brain and skull/rigid potting surfaces were tracked, and peak values of relative brain–skull displacement were extracted and found to be significantly less than values extracted from a previous axial plane model. In a finite element model of the sagittally transected neonatal porcine head, the brain–skull boundary condition was matched to the measured physical experiment data. Despite smaller sagittal plane displacements at the brain–skull boundary, the corresponding finite element boundary condition optimized for sagittal plane rotations is far less stiff than its axial counterpart, likely due to the prominent role of the boundary geometry in restricting interface movement. Finally, bridging veins were included in the finite element model. Varying the bridging vein mechanical behavior over a previously reported range had no influence on the brain–skull boundary displacements. This direction-specific sagittal plane boundary condition can be employed in finite element models of rapid sagittal head rotations. |
| first_indexed | 2024-12-12T03:35:25Z |
| format | Article |
| id | doaj.art-17edbe6cea14455fad0aa71bfceceef3 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T03:35:25Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-17edbe6cea14455fad0aa71bfceceef32022-12-22T00:39:48ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852018-02-01610.3389/fbioe.2018.00016317719Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head RotationsStephanie A. Pasquesi0Susan S. Margulies1Injury Biomechanics Laboratory, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United StatesInjury Biomechanics Laboratory, Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United StatesComputational models are valuable tools for studying tissue-level mechanisms of traumatic brain injury, but to produce more accurate estimates of tissue deformation, these models must be validated against experimental data. In this study, we present in situ measurements of brain–skull displacement in the neonatal piglet head (n = 3) at the sagittal midline during six rapid non-impact rotations (two rotations per specimen) with peak angular velocities averaging 51.7 ± 1.4 rad/s. Marks on the sagittally cut brain and skull/rigid potting surfaces were tracked, and peak values of relative brain–skull displacement were extracted and found to be significantly less than values extracted from a previous axial plane model. In a finite element model of the sagittally transected neonatal porcine head, the brain–skull boundary condition was matched to the measured physical experiment data. Despite smaller sagittal plane displacements at the brain–skull boundary, the corresponding finite element boundary condition optimized for sagittal plane rotations is far less stiff than its axial counterpart, likely due to the prominent role of the boundary geometry in restricting interface movement. Finally, bridging veins were included in the finite element model. Varying the bridging vein mechanical behavior over a previously reported range had no influence on the brain–skull boundary displacements. This direction-specific sagittal plane boundary condition can be employed in finite element models of rapid sagittal head rotations.http://journal.frontiersin.org/article/10.3389/fbioe.2018.00016/fullfinite element modelbrain–skull displacementboundary conditiontraumatic brain injurybridging vein |
| spellingShingle | Stephanie A. Pasquesi Susan S. Margulies Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations Frontiers in Bioengineering and Biotechnology finite element model brain–skull displacement boundary condition traumatic brain injury bridging vein |
| title | Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations |
| title_full | Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations |
| title_fullStr | Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations |
| title_full_unstemmed | Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations |
| title_short | Measurement and Finite Element Model Validation of Immature Porcine Brain–Skull Displacement during Rapid Sagittal Head Rotations |
| title_sort | measurement and finite element model validation of immature porcine brain skull displacement during rapid sagittal head rotations |
| topic | finite element model brain–skull displacement boundary condition traumatic brain injury bridging vein |
| url | http://journal.frontiersin.org/article/10.3389/fbioe.2018.00016/full |
| work_keys_str_mv | AT stephanieapasquesi measurementandfiniteelementmodelvalidationofimmatureporcinebrainskulldisplacementduringrapidsagittalheadrotations AT susansmargulies measurementandfiniteelementmodelvalidationofimmatureporcinebrainskulldisplacementduringrapidsagittalheadrotations |