Supercritical CO<sub>2</sub> Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate

Supercritical CO<sub>2</sub> Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate

In this work, Class 2 and Class 3 solvents contained in two corticosteroids, flunisolide (Fluni) and fluticasone propionate (Fluti), were reduced to a few ppm by supercritical CO<sub>2</sub> extraction. The process was carried out at pressures from 80 to 200 bar, temperatures of 40 °C an...

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Bibliographic Details
Main Authors: Lucia Baldino, Mariarosa Scognamiglio, Ernesto Reverchon
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceutics
Subjects:
supercritical CO<sub>2</sub> extraction
flunisolide
fluticasone propionate
organic solvent extraction
active pharmaceutical ingredients
Online Access:https://www.mdpi.com/1999-4923/13/5/612

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