Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?
Abstract There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-ind...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-06-01
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| Series: | Nutrition & Diabetes |
| Online Access: | https://doi.org/10.1038/s41387-022-00209-z |
| _version_ | 1818207719694270464 |
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| author | Lauren Carmichael Michelle A. Keske Andrew C. Betik Lewan Parker Barbara Brayner Katherine M. Roberts-Thomson Glenn D. Wadley D. Lee Hamilton Gunveen Kaur |
| author_facet | Lauren Carmichael Michelle A. Keske Andrew C. Betik Lewan Parker Barbara Brayner Katherine M. Roberts-Thomson Glenn D. Wadley D. Lee Hamilton Gunveen Kaur |
| author_sort | Lauren Carmichael |
| collection | DOAJ |
| description | Abstract There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance. These data suggest that impaired skeletal muscle microvascular blood flow is an early vascular step before the onset of insulin resistance. However, evidence of this is still lacking in humans. In this review, we summarise what is known about short-term high-calorie and/or high-fat feeding in humans. We also explore selected animal studies to identify potential mechanisms. We discuss future directions aimed at better understanding the ‘early’ vascular mechanisms that lead to insulin resistance as this will provide the opportunity for much earlier screening and timing of intervention to assist in preventing type 2 diabetes. |
| first_indexed | 2024-12-12T04:33:24Z |
| format | Article |
| id | doaj.art-17f07758d47c4dd99eedfd69b965891b |
| institution | Directory Open Access Journal |
| issn | 2044-4052 |
| language | English |
| last_indexed | 2024-12-12T04:33:24Z |
| publishDate | 2022-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Nutrition & Diabetes |
| spelling | doaj.art-17f07758d47c4dd99eedfd69b965891b2022-12-22T00:38:02ZengNature Publishing GroupNutrition & Diabetes2044-40522022-06-0112111210.1038/s41387-022-00209-zIs vascular insulin resistance an early step in diet-induced whole-body insulin resistance?Lauren Carmichael0Michelle A. Keske1Andrew C. Betik2Lewan Parker3Barbara Brayner4Katherine M. Roberts-Thomson5Glenn D. Wadley6D. Lee Hamilton7Gunveen Kaur8Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityInstitute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin UniversityAbstract There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-induced insulin-resistant rodents, insulin-mediated skeletal muscle microvascular blood flow is impaired post-short-term high fat feeding, and this occurs before the development of myocyte or whole-body insulin resistance. These data suggest that impaired skeletal muscle microvascular blood flow is an early vascular step before the onset of insulin resistance. However, evidence of this is still lacking in humans. In this review, we summarise what is known about short-term high-calorie and/or high-fat feeding in humans. We also explore selected animal studies to identify potential mechanisms. We discuss future directions aimed at better understanding the ‘early’ vascular mechanisms that lead to insulin resistance as this will provide the opportunity for much earlier screening and timing of intervention to assist in preventing type 2 diabetes.https://doi.org/10.1038/s41387-022-00209-z |
| spellingShingle | Lauren Carmichael Michelle A. Keske Andrew C. Betik Lewan Parker Barbara Brayner Katherine M. Roberts-Thomson Glenn D. Wadley D. Lee Hamilton Gunveen Kaur Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? Nutrition & Diabetes |
| title | Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? |
| title_full | Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? |
| title_fullStr | Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? |
| title_full_unstemmed | Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? |
| title_short | Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? |
| title_sort | is vascular insulin resistance an early step in diet induced whole body insulin resistance |
| url | https://doi.org/10.1038/s41387-022-00209-z |
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