Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance?

Abstract There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resistant individuals. Studies suggest that in diet-ind...

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Bibliographic Details
Main Authors: Lauren Carmichael, Michelle A. Keske, Andrew C. Betik, Lewan Parker, Barbara Brayner, Katherine M. Roberts-Thomson, Glenn D. Wadley, D. Lee Hamilton, Gunveen Kaur
Format: Article
Language:English
Published: Nature Publishing Group 2022-06-01
Series:Nutrition & Diabetes
Online Access:https://doi.org/10.1038/s41387-022-00209-z

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