Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity
Data independent acquisition (DIA) has been gaining momentum in clinical proteomics. Here, the authors create a benchmark dataset comprising inter-patient heterogeneity to compare popular DIA data analysis workflows for identifying differentially abundant proteins.
Main Authors: | Klemens Fröhlich, Eva Brombacher, Matthias Fahrner, Daniel Vogele, Lucas Kook, Niko Pinter, Peter Bronsert, Sylvia Timme-Bronsert, Alexander Schmidt, Katja Bärenfaller, Clemens Kreutz, Oliver Schilling |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30094-0 |
Similar Items
-
Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling
by: Janina Werner, et al.
Published: (2023-02-01) -
Circulating Epithelial Cells in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas
by: Jasmina Kuvendjiska, et al.
Published: (2023-07-01) -
Protocol of the HISTOTHERM study: assessing the response to hyperthermia and hypofractionated radiotherapy in recurrent breast cancer
by: Andreas R. Thomsen, et al.
Published: (2023-12-01) -
A Systematic Evaluation of Semispecific Peptide Search Parameter Enables Identification of Previously Undescribed N-Terminal Peptides and Conserved Proteolytic Processing in Cancer Cell Lines
by: Matthias Fahrner, et al.
Published: (2021-05-01) -
Characterizing the omics landscape based on 10,000+ datasets
by: Eva Brombacher, et al.
Published: (2025-01-01)