Comparison of eye movements in schizophrenia and autism spectrum disorder
Abstract Aim Eye movement abnormalities are often associated with psychiatric illness. Subjects with either schizophrenia or autism spectrum disorder (ASD) have been reported to show eye movement abnormalities. However, it is still unclear whether eye movement abnormalities in schizophrenia and in A...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-03-01
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| Series: | Neuropsychopharmacology Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/npr2.12085 |
| _version_ | 1811177977302482944 |
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| author | Tomoko Shiino Kenichiro Miura Michiko Fujimoto Noriko Kudo Hidenaga Yamamori Yuka Yasuda Manabu Ikeda Ryota Hashimoto |
| author_facet | Tomoko Shiino Kenichiro Miura Michiko Fujimoto Noriko Kudo Hidenaga Yamamori Yuka Yasuda Manabu Ikeda Ryota Hashimoto |
| author_sort | Tomoko Shiino |
| collection | DOAJ |
| description | Abstract Aim Eye movement abnormalities are often associated with psychiatric illness. Subjects with either schizophrenia or autism spectrum disorder (ASD) have been reported to show eye movement abnormalities. However, it is still unclear whether eye movement abnormalities in schizophrenia and in ASD have common features. This study aimed to understand the similarities/differences in eye movement abnormalities of subjects with schizophrenia and those with ASD. Methods We analyzed 75 eye movement characteristics of 83 subjects with schizophrenia, 17 subjects with ASD and 255 healthy controls that were collected during fixation, smooth pursuit and free viewing tasks using analysis of covariance with the covariates age and sex. Results We found significant effects across groups on 21 eye movement characteristics, of which 4 characteristics had large effect sizes. Post hoc multiple comparisons indicated significant differences between the subjects with schizophrenia and healthy controls across all 21 characteristics. On the other hand, no significant difference between the ASD group and healthy control group was found. Instead, the subjects with ASD showed significant differences from the subjects with schizophrenia in 5 eye movement characteristics during the free viewing and smooth pursuit eye movements. Conclusions The present results suggest that eye movement abnormalities in the subjects with ASD are different from those with schizophrenia and that the tasks in this study are suitable to detect eye movement abnormality in schizophrenia. Thus, the eye movement examinations used here may distinguish subjects with schizophrenia from those with ASD. |
| first_indexed | 2024-04-11T06:10:29Z |
| format | Article |
| id | doaj.art-17f3a0aab57a431caf8795cbcaa0fb46 |
| institution | Directory Open Access Journal |
| issn | 2574-173X |
| language | English |
| last_indexed | 2024-04-11T06:10:29Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neuropsychopharmacology Reports |
| spelling | doaj.art-17f3a0aab57a431caf8795cbcaa0fb462022-12-22T04:41:16ZengWileyNeuropsychopharmacology Reports2574-173X2020-03-01401929510.1002/npr2.12085Comparison of eye movements in schizophrenia and autism spectrum disorderTomoko Shiino0Kenichiro Miura1Michiko Fujimoto2Noriko Kudo3Hidenaga Yamamori4Yuka Yasuda5Manabu Ikeda6Ryota Hashimoto7Department of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanDepartment of Psychiatry Graduate School of Medicine Osaka University Suita JapanDepartment of Pathology of Mental Diseases National Institute of Mental Health National Center of Neurology and Psychiatry Kodaira JapanAbstract Aim Eye movement abnormalities are often associated with psychiatric illness. Subjects with either schizophrenia or autism spectrum disorder (ASD) have been reported to show eye movement abnormalities. However, it is still unclear whether eye movement abnormalities in schizophrenia and in ASD have common features. This study aimed to understand the similarities/differences in eye movement abnormalities of subjects with schizophrenia and those with ASD. Methods We analyzed 75 eye movement characteristics of 83 subjects with schizophrenia, 17 subjects with ASD and 255 healthy controls that were collected during fixation, smooth pursuit and free viewing tasks using analysis of covariance with the covariates age and sex. Results We found significant effects across groups on 21 eye movement characteristics, of which 4 characteristics had large effect sizes. Post hoc multiple comparisons indicated significant differences between the subjects with schizophrenia and healthy controls across all 21 characteristics. On the other hand, no significant difference between the ASD group and healthy control group was found. Instead, the subjects with ASD showed significant differences from the subjects with schizophrenia in 5 eye movement characteristics during the free viewing and smooth pursuit eye movements. Conclusions The present results suggest that eye movement abnormalities in the subjects with ASD are different from those with schizophrenia and that the tasks in this study are suitable to detect eye movement abnormality in schizophrenia. Thus, the eye movement examinations used here may distinguish subjects with schizophrenia from those with ASD.https://doi.org/10.1002/npr2.12085autism spectrum disordereye movementfree viewingschizophreniasmooth pursuit |
| spellingShingle | Tomoko Shiino Kenichiro Miura Michiko Fujimoto Noriko Kudo Hidenaga Yamamori Yuka Yasuda Manabu Ikeda Ryota Hashimoto Comparison of eye movements in schizophrenia and autism spectrum disorder Neuropsychopharmacology Reports autism spectrum disorder eye movement free viewing schizophrenia smooth pursuit |
| title | Comparison of eye movements in schizophrenia and autism spectrum disorder |
| title_full | Comparison of eye movements in schizophrenia and autism spectrum disorder |
| title_fullStr | Comparison of eye movements in schizophrenia and autism spectrum disorder |
| title_full_unstemmed | Comparison of eye movements in schizophrenia and autism spectrum disorder |
| title_short | Comparison of eye movements in schizophrenia and autism spectrum disorder |
| title_sort | comparison of eye movements in schizophrenia and autism spectrum disorder |
| topic | autism spectrum disorder eye movement free viewing schizophrenia smooth pursuit |
| url | https://doi.org/10.1002/npr2.12085 |
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