Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

Hydrogen Sulfide Ameliorates Homocysteine-Induced Cardiac Remodeling and Dysfunction

Patients with diabetes, a methionine-rich meat diet, or certain genetic polymorphisms show elevated levels of homocysteine (Hcy), which is strongly associated with the development of cardiovascular disease including diabetic cardiomyopathy. However, reducing Hcy levels with folate shows no beneficia...

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Bibliographic Details
Main Authors: Sumit Kar, Hamid R. Shahshahan, Tyler N. Kambis, Santosh K. Yadav, Zhen Li, David J. Lefer, Paras K. Mishra
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Physiology
Subjects:
hyperhomocysteinemia
H2S
fibrosis
hypertrophy
cardioprotection
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00598/full

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