Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor
<strong>Objective-</strong> Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore...
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| Format: | Article |
| Language: | English |
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Iranian Veterinary Surgery Association (IVSA)
2020-04-01
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| Series: | Iranian Journal of Veterinary Surgery |
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| Online Access: | http://www.ivsajournals.com/article_100946_f1cd7411335839924ec4b2a984142948.pdf |
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| author | Esmaeal Tamaddonfard Amir Erfanparast Sina Tamaddonfard Nabat Nagshbandi Somayyeh Naderi |
| author_facet | Esmaeal Tamaddonfard Amir Erfanparast Sina Tamaddonfard Nabat Nagshbandi Somayyeh Naderi |
| author_sort | Esmaeal Tamaddonfard |
| collection | DOAJ |
| description | <strong>Objective-</strong> Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore the possible mechanism, yohimbine (an α2-adrenergic receptor antagonist) was also used.<br /> <strong>Design-</strong> An experimental study.<br /> <strong>Animals–</strong> Forty-eight healthy male Wistar rats. <br /> <strong>Procedures–</strong> Rats were divided into eight groups with six rats in each group to receive intraperitoneal injection of normal saline, oral administration of curcumin (12.5, 50 and 200 mg/kg), intraperitoneal injection of yohimbine (0.5 and 2 mg/kg), and oral administration of curcumin (12.5 mg/kg) plus intraperitoneal injection of yohimbine (0.5 mg/kg). After these treatments, ketamine (100 mg/kg) and xylazine (10 mg/kg) were intraperitoneally administered to all groups. Blood glucose concentration was measured at 60 and 5 min before and at, 30, 60, 90 and 120 min after ketamine-xylazine injection. Serum insulin concentration was measured by ELISA kit at the end of experiment.<br /> <strong>Results-</strong> Ketamin-xylazine increased blood glucose and decreased serum insulin. Curcumin lowered increased blood glucose and increased decreased serum insulin. Yohimbine prevented the hyperglycemia and hypoinsulinemia induced by ketamin-xylazine produced the same results as curcumin. Low doses of curcumin and yohimbine induced documented hypoglycemic and hyperinsulinemic effects.<br /> <strong>Conclusion and Clinical Relevance-</strong> Based on the results, it is concluded that curcumin improves hyperglycemia and hypoinsulinemia induced by ketamine- xylazine and α2-adrenergic receptor may involve in this effect. |
| first_indexed | 2024-12-23T10:42:56Z |
| format | Article |
| id | doaj.art-17f422917b004017909407df35aaba94 |
| institution | Directory Open Access Journal |
| issn | 2008-3033 2676-6299 |
| language | English |
| last_indexed | 2024-12-23T10:42:56Z |
| publishDate | 2020-04-01 |
| publisher | Iranian Veterinary Surgery Association (IVSA) |
| record_format | Article |
| series | Iranian Journal of Veterinary Surgery |
| spelling | doaj.art-17f422917b004017909407df35aaba942022-12-21T17:50:06ZengIranian Veterinary Surgery Association (IVSA)Iranian Journal of Veterinary Surgery2008-30332676-62992020-04-01151536110.30500/ivsa.2020.189763.1186100946Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic ReceptorEsmaeal Tamaddonfard0Amir Erfanparast1Sina Tamaddonfard2Nabat Nagshbandi3Somayyeh Naderi4Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran<strong>Objective-</strong> Medicinal plants and their active constituents are frequently used components for treating hyperglycemia. In the present study, the effect of curcumin was investigated on acute hyperglycemia and hyperinsulinemia induced by ketamine-xylazine in rats. To explore the possible mechanism, yohimbine (an α2-adrenergic receptor antagonist) was also used.<br /> <strong>Design-</strong> An experimental study.<br /> <strong>Animals–</strong> Forty-eight healthy male Wistar rats. <br /> <strong>Procedures–</strong> Rats were divided into eight groups with six rats in each group to receive intraperitoneal injection of normal saline, oral administration of curcumin (12.5, 50 and 200 mg/kg), intraperitoneal injection of yohimbine (0.5 and 2 mg/kg), and oral administration of curcumin (12.5 mg/kg) plus intraperitoneal injection of yohimbine (0.5 mg/kg). After these treatments, ketamine (100 mg/kg) and xylazine (10 mg/kg) were intraperitoneally administered to all groups. Blood glucose concentration was measured at 60 and 5 min before and at, 30, 60, 90 and 120 min after ketamine-xylazine injection. Serum insulin concentration was measured by ELISA kit at the end of experiment.<br /> <strong>Results-</strong> Ketamin-xylazine increased blood glucose and decreased serum insulin. Curcumin lowered increased blood glucose and increased decreased serum insulin. Yohimbine prevented the hyperglycemia and hypoinsulinemia induced by ketamin-xylazine produced the same results as curcumin. Low doses of curcumin and yohimbine induced documented hypoglycemic and hyperinsulinemic effects.<br /> <strong>Conclusion and Clinical Relevance-</strong> Based on the results, it is concluded that curcumin improves hyperglycemia and hypoinsulinemia induced by ketamine- xylazine and α2-adrenergic receptor may involve in this effect.http://www.ivsajournals.com/article_100946_f1cd7411335839924ec4b2a984142948.pdfketamine-xylazinecurcuminhyperglycemiainsulinrats |
| spellingShingle | Esmaeal Tamaddonfard Amir Erfanparast Sina Tamaddonfard Nabat Nagshbandi Somayyeh Naderi Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor Iranian Journal of Veterinary Surgery ketamine-xylazine curcumin hyperglycemia insulin rats |
| title | Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor |
| title_full | Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor |
| title_fullStr | Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor |
| title_full_unstemmed | Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor |
| title_short | Effect of Curcumin, an Active Substance of Turmeric, on Acute Hyperglycemia Induced by Ketamine-Xylazine: Role of α2-Adrenergic Receptor |
| title_sort | effect of curcumin an active substance of turmeric on acute hyperglycemia induced by ketamine xylazine role of α2 adrenergic receptor |
| topic | ketamine-xylazine curcumin hyperglycemia insulin rats |
| url | http://www.ivsajournals.com/article_100946_f1cd7411335839924ec4b2a984142948.pdf |
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