Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components
Depression is a mental disorder that affects more than 300 million people worldwide. The medications available for treatment take a long time to exhibit therapeutic results and present several side effects. Furthermore, there is a decrease in the quality of life of people suffering from this afflict...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/11/9244 |
| _version_ | 1797597454173995008 |
|---|---|
| author | Emily Christie M. Fonseca Lanalice R. Ferreira Pablo Luis B. Figueiredo Cristiane do Socorro F. Maia William N. Setzer Joyce Kelly R. Da Silva |
| author_facet | Emily Christie M. Fonseca Lanalice R. Ferreira Pablo Luis B. Figueiredo Cristiane do Socorro F. Maia William N. Setzer Joyce Kelly R. Da Silva |
| author_sort | Emily Christie M. Fonseca |
| collection | DOAJ |
| description | Depression is a mental disorder that affects more than 300 million people worldwide. The medications available for treatment take a long time to exhibit therapeutic results and present several side effects. Furthermore, there is a decrease in the quality of life of people suffering from this affliction. Essential oils are traditionally used to relieve the symptoms of depression due to the properties of the constituents of these oils to cross the blood–brain barrier acting on depression-related biological receptors associated with reduced toxicity and side effects. In addition, compared to traditional drugs, they have several administration forms. This review provides a comprehensive assessment of studies on plants whose essential oil has exhibit antidepressant activity in the past decade and the mechanism of action of the major components and models tested. An additional in silico study was conducted with the frequent compounds in the composition of these essential oils, providing a molecular approach to the mechanism of action that has been reported in the past decade. This review is valuable for the development of potential antidepressant medications in addition to providing a molecular approach to the antidepressant mechanism of action of the major volatile compounds that have been reported in the past decade. |
| first_indexed | 2024-03-11T03:05:21Z |
| format | Article |
| id | doaj.art-17f537ecc8264693b8d11df94874c6ac |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:05:21Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-17f537ecc8264693b8d11df94874c6ac2023-11-18T07:56:33ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411924410.3390/ijms24119244Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical ComponentsEmily Christie M. Fonseca0Lanalice R. Ferreira1Pablo Luis B. Figueiredo2Cristiane do Socorro F. Maia3William N. Setzer4Joyce Kelly R. Da Silva5Programa de Pós-Graduação em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém 66075-110, BrazilPrograma de Pós-Graduação em Química, Universidade Federal do Pará, Belém 66075-110, BrazilLaboratório de Química dos Produtos Naturais, Centro de Ciências Biológicas e da Saúde, Universidade do Estado do Pará, Belém 66087-662, BrazilPrograma de Pós-Graduação em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém 66075-110, BrazilAromatic Plant Research Center, Lehi, UT 84043, USAPrograma de Pós-Graduação em Farmacologia e Bioquímica, Universidade Federal do Pará, Belém 66075-110, BrazilDepression is a mental disorder that affects more than 300 million people worldwide. The medications available for treatment take a long time to exhibit therapeutic results and present several side effects. Furthermore, there is a decrease in the quality of life of people suffering from this affliction. Essential oils are traditionally used to relieve the symptoms of depression due to the properties of the constituents of these oils to cross the blood–brain barrier acting on depression-related biological receptors associated with reduced toxicity and side effects. In addition, compared to traditional drugs, they have several administration forms. This review provides a comprehensive assessment of studies on plants whose essential oil has exhibit antidepressant activity in the past decade and the mechanism of action of the major components and models tested. An additional in silico study was conducted with the frequent compounds in the composition of these essential oils, providing a molecular approach to the mechanism of action that has been reported in the past decade. This review is valuable for the development of potential antidepressant medications in addition to providing a molecular approach to the antidepressant mechanism of action of the major volatile compounds that have been reported in the past decade.https://www.mdpi.com/1422-0067/24/11/9244monoterpenessesquiterpenesphenylpropanoidslinaloolβ-caryophyllene5-HT receptor |
| spellingShingle | Emily Christie M. Fonseca Lanalice R. Ferreira Pablo Luis B. Figueiredo Cristiane do Socorro F. Maia William N. Setzer Joyce Kelly R. Da Silva Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components International Journal of Molecular Sciences monoterpenes sesquiterpenes phenylpropanoids linalool β-caryophyllene 5-HT receptor |
| title | Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components |
| title_full | Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components |
| title_fullStr | Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components |
| title_full_unstemmed | Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components |
| title_short | Antidepressant Effects of Essential Oils: A Review of the Past Decade (2012–2022) and Molecular Docking Study of Their Major Chemical Components |
| title_sort | antidepressant effects of essential oils a review of the past decade 2012 2022 and molecular docking study of their major chemical components |
| topic | monoterpenes sesquiterpenes phenylpropanoids linalool β-caryophyllene 5-HT receptor |
| url | https://www.mdpi.com/1422-0067/24/11/9244 |
| work_keys_str_mv | AT emilychristiemfonseca antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents AT lanalicerferreira antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents AT pabloluisbfigueiredo antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents AT cristianedosocorrofmaia antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents AT williamnsetzer antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents AT joycekellyrdasilva antidepressanteffectsofessentialoilsareviewofthepastdecade20122022andmoleculardockingstudyoftheirmajorchemicalcomponents |