Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction

Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction

Abstract Ischemia-reperfusion (I/R) injury is a challenging clinical problem, especially injuries involving the gastrointestinal tract. Mitochondrial DNA (mtDNA) is released upon cell death and stress, and can induce the inflammatory response. We aimed to investigate the role of mtDNA in the pathoge...

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Bibliographic Details
Main Authors:	Qiongyuan Hu, Huajian Ren, Jianan Ren, Qinjie Liu, Jie Wu, Xiuwen Wu, Guanwei Li, Gefei Wang, Guosheng Gu, Kun Guo, Zhiwu Hong, Song Liu, Jieshou Li
Format:	Article
Language:	English
Published:	Nature Portfolio 2018-05-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-018-25387-8

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