Preparation and Characterization of Nanosuspension of Aprepitant by H96 Process
Purpose: Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2016-03-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: | |
| Online Access: | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-83.pdf |
| _version_ | 1811286723992223744 |
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| author | Sunethra Kalvakuntla Mangesh Deshpande Zenab Attari Koteshwara Kunnatur B |
| author_facet | Sunethra Kalvakuntla Mangesh Deshpande Zenab Attari Koteshwara Kunnatur B |
| author_sort | Sunethra Kalvakuntla |
| collection | DOAJ |
| description | Purpose: Nanosuspension in drug delivery is known to improve
solubility, dissolution and eventually bioavailability of the drugs. The
purpose of the study was to compare particle size of nanosuspensions prepared
by the first generation approach and H96 approach and to evaluate the
effectiveness of H96 approach.
Methods: The nanosuspension of aprepitant was prepared by HPH
and H96 approach. The prepared nanosuspensions were characterized for their
particle size and zeta potential. The optimized nanosuspension was further
evaluated for DSC, FT-IR, solubility and dissolution.
Results: The optimized nanosuspension (NCLH5) prepared using
combination of tween 80 and poloxamer 188 as stabilizer, showed particle size
of 35.82 nm and improved solubility and dissolution profile over pure drug. NCLH5 was chosen optimized formulation and
further evaluated for other parameters after lyophilization. Lyophilization
resulted in increase in particle size. The solubility and dissolution studies
showed favorable increase in the performance. The FT-IR and DSC analysis showed
change in the crystallinity after nanosizing.
Conclusion: The
observations indicated that lyophilization prior to high pressure
homogenization resulted in efficient particle size reduction yielding smaller
particles than first generation preparation technique. H96 is a good and easy alternative to achieve efficient particle size
reduction of drug in lesser time and increase its solubility and dissolution. |
| first_indexed | 2024-04-13T03:06:09Z |
| format | Article |
| id | doaj.art-17f66711583f4de3983db5b27cb6caf4 |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-13T03:06:09Z |
| publishDate | 2016-03-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-17f66711583f4de3983db5b27cb6caf42022-12-22T03:05:15ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082016-03-0161839010.15171/apb.2016.013APB_3101_20150518141111Preparation and Characterization of Nanosuspension of Aprepitant by H96 ProcessSunethra Kalvakuntla0Mangesh Deshpande1Zenab Attari2Koteshwara Kunnatur B3Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal.Dr. Reddy’s Laboratories Ltd., Hyderabad, India.Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal.Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal.Purpose: Nanosuspension in drug delivery is known to improve solubility, dissolution and eventually bioavailability of the drugs. The purpose of the study was to compare particle size of nanosuspensions prepared by the first generation approach and H96 approach and to evaluate the effectiveness of H96 approach. Methods: The nanosuspension of aprepitant was prepared by HPH and H96 approach. The prepared nanosuspensions were characterized for their particle size and zeta potential. The optimized nanosuspension was further evaluated for DSC, FT-IR, solubility and dissolution. Results: The optimized nanosuspension (NCLH5) prepared using combination of tween 80 and poloxamer 188 as stabilizer, showed particle size of 35.82 nm and improved solubility and dissolution profile over pure drug. NCLH5 was chosen optimized formulation and further evaluated for other parameters after lyophilization. Lyophilization resulted in increase in particle size. The solubility and dissolution studies showed favorable increase in the performance. The FT-IR and DSC analysis showed change in the crystallinity after nanosizing. Conclusion: The observations indicated that lyophilization prior to high pressure homogenization resulted in efficient particle size reduction yielding smaller particles than first generation preparation technique. H96 is a good and easy alternative to achieve efficient particle size reduction of drug in lesser time and increase its solubility and dissolution.http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-83.pdfLyophilizationNanosuspensionParticle sizeSecond generation approachHigh pressure homogenization |
| spellingShingle | Sunethra Kalvakuntla Mangesh Deshpande Zenab Attari Koteshwara Kunnatur B Preparation and Characterization of Nanosuspension of Aprepitant by H96 Process Advanced Pharmaceutical Bulletin Lyophilization Nanosuspension Particle size Second generation approach High pressure homogenization |
| title | Preparation and
Characterization of Nanosuspension of Aprepitant by H96 Process |
| title_full | Preparation and
Characterization of Nanosuspension of Aprepitant by H96 Process |
| title_fullStr | Preparation and
Characterization of Nanosuspension of Aprepitant by H96 Process |
| title_full_unstemmed | Preparation and
Characterization of Nanosuspension of Aprepitant by H96 Process |
| title_short | Preparation and
Characterization of Nanosuspension of Aprepitant by H96 Process |
| title_sort | preparation and characterization of nanosuspension of aprepitant by h96 process |
| topic | Lyophilization Nanosuspension Particle size Second generation approach High pressure homogenization |
| url | http://journals.tbzmed.ac.ir/APB/Manuscript/APB-6-83.pdf |
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