Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications
In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-09-01
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| Series: | JID Innovations |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667026721000606 |
| _version_ | 1818354142251319296 |
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| author | Juan-Manuel Leyva-Castillo Raif S. Geha |
| author_facet | Juan-Manuel Leyva-Castillo Raif S. Geha |
| author_sort | Juan-Manuel Leyva-Castillo |
| collection | DOAJ |
| description | In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show that the circulating subset of skin ILC2s migrates to draining lymph nodes during hapten-induced cutaneous inflammation to potentially enhance the adaptive immune response. |
| first_indexed | 2024-12-13T19:20:43Z |
| format | Article |
| id | doaj.art-17f669241eb54d7a9d91ccbb8a612b3e |
| institution | Directory Open Access Journal |
| issn | 2667-0267 |
| language | English |
| last_indexed | 2024-12-13T19:20:43Z |
| publishDate | 2021-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JID Innovations |
| spelling | doaj.art-17f669241eb54d7a9d91ccbb8a612b3e2022-12-21T23:34:09ZengElsevierJID Innovations2667-02672021-09-0113100059Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical ImplicationsJuan-Manuel Leyva-Castillo0Raif S. Geha1Division of Immunology, Boston Childrens Hospital, Boston, Massachusetts, USA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USADivision of Immunology, Boston Childrens Hospital, Boston, Massachusetts, USA; Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA; Correspondence: Raif S. Geha, Division of Immunology, Boston Children's Hospital, 1 Blackfan Circle, Karp 10, Boston, Massachusetts 02115, USA.In a new article published in JID Innovations, Nakatani-Kusakabe et al. (2021) show that type 2 innate lymphoid cells (ILC2s) in the skin of mice with IL-33 overexpression in keratinocytes are heterogeneous and consist of two distinct populations: skin-resident ILC2s and circulating ILC2s. They show that the circulating subset of skin ILC2s migrates to draining lymph nodes during hapten-induced cutaneous inflammation to potentially enhance the adaptive immune response.http://www.sciencedirect.com/science/article/pii/S2667026721000606 |
| spellingShingle | Juan-Manuel Leyva-Castillo Raif S. Geha Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications JID Innovations |
| title | Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications |
| title_full | Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications |
| title_fullStr | Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications |
| title_full_unstemmed | Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications |
| title_short | Cutaneous Type 2 Innate Lymphoid Cells Come in Distinct FlavorsClinical Implications |
| title_sort | cutaneous type 2 innate lymphoid cells come in distinct flavorsclinical implications |
| url | http://www.sciencedirect.com/science/article/pii/S2667026721000606 |
| work_keys_str_mv | AT juanmanuelleyvacastillo cutaneoustype2innatelymphoidcellscomeindistinctflavorsclinicalimplications AT raifsgeha cutaneoustype2innatelymphoidcellscomeindistinctflavorsclinicalimplications |