Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes
Post-prandial hyperglycemia can be relevant in developing early manifestations of atherosclerosis. EVOO (Extra Virgin Olive Oil), rich in saturated fatty acids and commonly used in the Mediterranean diet, seems to control post-prandial hyperglycemia better than butter. Subjects with type 1 diabetes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/7/2436 |
| _version_ | 1797526366057398272 |
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| author | Antonio Cutruzzolà Martina Parise Rosarina Vallelunga Francesco Lamanna Agostino Gnasso Concetta Irace |
| author_facet | Antonio Cutruzzolà Martina Parise Rosarina Vallelunga Francesco Lamanna Agostino Gnasso Concetta Irace |
| author_sort | Antonio Cutruzzolà |
| collection | DOAJ |
| description | Post-prandial hyperglycemia can be relevant in developing early manifestations of atherosclerosis. EVOO (Extra Virgin Olive Oil), rich in saturated fatty acids and commonly used in the Mediterranean diet, seems to control post-prandial hyperglycemia better than butter. Subjects with type 1 diabetes are at higher risk of developing cardiovascular disease and show endothelial dysfunction, an early manifestation of atherosclerosis in the first years of the disease. Our study aims to evaluate whether EVOO and butter influence endothelial function in subjects with type 1 diabetes when added to a single high glycemic index (HGI) meal. In this exploratory cross-over study, 10 subjects with type 1 diabetes and 6 healthy subjects were scheduled to receive two types of HGI meals: one enriched with EVOO and one with butter. Before and after each test meal at different time points, all subjects underwent the evaluation of endothelial function by flow-mediated dilation technique, glucose and lipids measurements, and gastric emptying assessment by ultrasound. Flow-mediated dilation significantly increased after EVOO-enriched meal compared with butter in subjects with type 1 diabetes (two-way-repeated measurements ANOVA, <i>p</i> = 0.007). In patients with type 1 diabetes, the add-on of EVOO to HGI meal improves vascular function compared to butter, which has detrimental effects. |
| first_indexed | 2024-03-10T09:29:13Z |
| format | Article |
| id | doaj.art-17f6a082ceec4bf79c6846b523627563 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T09:29:13Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-17f6a082ceec4bf79c6846b5236275632023-11-22T04:37:27ZengMDPI AGNutrients2072-66432021-07-01137243610.3390/nu13072436Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 DiabetesAntonio Cutruzzolà0Martina Parise1Rosarina Vallelunga2Francesco Lamanna3Agostino Gnasso4Concetta Irace5Dipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, 88100 Catanzaro, ItalyDipartimento di Scienze della Salute, University Magna Græcia, 88100 Catanzaro, ItalyDipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, 88100 Catanzaro, ItalyDipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, 88100 Catanzaro, ItalyDipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, 88100 Catanzaro, ItalyDipartimento di Scienze della Salute, University Magna Græcia, 88100 Catanzaro, ItalyPost-prandial hyperglycemia can be relevant in developing early manifestations of atherosclerosis. EVOO (Extra Virgin Olive Oil), rich in saturated fatty acids and commonly used in the Mediterranean diet, seems to control post-prandial hyperglycemia better than butter. Subjects with type 1 diabetes are at higher risk of developing cardiovascular disease and show endothelial dysfunction, an early manifestation of atherosclerosis in the first years of the disease. Our study aims to evaluate whether EVOO and butter influence endothelial function in subjects with type 1 diabetes when added to a single high glycemic index (HGI) meal. In this exploratory cross-over study, 10 subjects with type 1 diabetes and 6 healthy subjects were scheduled to receive two types of HGI meals: one enriched with EVOO and one with butter. Before and after each test meal at different time points, all subjects underwent the evaluation of endothelial function by flow-mediated dilation technique, glucose and lipids measurements, and gastric emptying assessment by ultrasound. Flow-mediated dilation significantly increased after EVOO-enriched meal compared with butter in subjects with type 1 diabetes (two-way-repeated measurements ANOVA, <i>p</i> = 0.007). In patients with type 1 diabetes, the add-on of EVOO to HGI meal improves vascular function compared to butter, which has detrimental effects.https://www.mdpi.com/2072-6643/13/7/2436EVOObutterdietary fatMediterranean dietendothelial functionflow-mediated dilation |
| spellingShingle | Antonio Cutruzzolà Martina Parise Rosarina Vallelunga Francesco Lamanna Agostino Gnasso Concetta Irace Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes Nutrients EVOO butter dietary fat Mediterranean diet endothelial function flow-mediated dilation |
| title | Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes |
| title_full | Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes |
| title_fullStr | Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes |
| title_full_unstemmed | Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes |
| title_short | Effect of Extra Virgin Olive Oil and Butter on Endothelial Function in Type 1 Diabetes |
| title_sort | effect of extra virgin olive oil and butter on endothelial function in type 1 diabetes |
| topic | EVOO butter dietary fat Mediterranean diet endothelial function flow-mediated dilation |
| url | https://www.mdpi.com/2072-6643/13/7/2436 |
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