Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation

Inhibitory Mechanism of Baicalein on Acetylcholinesterase: Inhibitory Interaction, Conformational Change, and Computational Simulation

Alzheimer’s disease (AD) is the most prevalent chronic neurodegenerative disease in elderly individuals, causing dementia. Acetylcholinesterase (AChE) is regarded as one of the most popular drug targets for AD. Herbal secondary metabolites are frequently cited as a major source of AChE inhibitors. I...

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Bibliographic Details
Main Authors:	Yijing Liao, Xing Hu, Junhui Pan, Guowen Zhang
Format:	Article
Language:	English
Published:	MDPI AG 2022-01-01
Series:	Foods
Subjects:	baicalein acetylcholinesterase inhibitory mechanism conformational change molecular docking molecular dynamics simulation
Online Access:	https://www.mdpi.com/2304-8158/11/2/168

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