Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics
Despite extensive research, resistance to chemotherapy still poses a major obstacle in clinical oncology. An exciting strategy to circumvent chemoresistance involves the identification and subsequent disruption of cellular processes that are aberrantly altered in oncogenic states. Upon chemotherapeu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/12/3669 |
| _version_ | 1797545493594636288 |
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| author | Xingjian Zhai Yassine El Hiani |
| author_facet | Xingjian Zhai Yassine El Hiani |
| author_sort | Xingjian Zhai |
| collection | DOAJ |
| description | Despite extensive research, resistance to chemotherapy still poses a major obstacle in clinical oncology. An exciting strategy to circumvent chemoresistance involves the identification and subsequent disruption of cellular processes that are aberrantly altered in oncogenic states. Upon chemotherapeutic challenges, lysosomes are deemed to be essential mediators that enable cellular adaptation to stress conditions. Therefore, lysosomes potentially hold the key to disarming the fundamental mechanisms of chemoresistance. This review explores modes of action of classical chemotherapeutic agents, adaptive response of the lysosomes to cell stress, and presents physiological and pharmacological insights pertaining to drug compartmentalization, sequestration, and extracellular clearance through the lens of lysosomes. |
| first_indexed | 2024-03-10T14:16:13Z |
| format | Article |
| id | doaj.art-17f6dbeac51c41cc9c93a61a033129d0 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:16:13Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-17f6dbeac51c41cc9c93a61a033129d02023-11-20T23:45:40ZengMDPI AGCancers2072-66942020-12-011212366910.3390/cancers12123669Getting Lost in the Cell–Lysosomal Entrapment of ChemotherapeuticsXingjian Zhai0Yassine El Hiani1Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaDepartment of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, NS B3H 4R2, CanadaDespite extensive research, resistance to chemotherapy still poses a major obstacle in clinical oncology. An exciting strategy to circumvent chemoresistance involves the identification and subsequent disruption of cellular processes that are aberrantly altered in oncogenic states. Upon chemotherapeutic challenges, lysosomes are deemed to be essential mediators that enable cellular adaptation to stress conditions. Therefore, lysosomes potentially hold the key to disarming the fundamental mechanisms of chemoresistance. This review explores modes of action of classical chemotherapeutic agents, adaptive response of the lysosomes to cell stress, and presents physiological and pharmacological insights pertaining to drug compartmentalization, sequestration, and extracellular clearance through the lens of lysosomes.https://www.mdpi.com/2072-6694/12/12/3669lysosomeslysosomal entrapmentchemotherapeuticschemoresistancecancer therapy |
| spellingShingle | Xingjian Zhai Yassine El Hiani Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics Cancers lysosomes lysosomal entrapment chemotherapeutics chemoresistance cancer therapy |
| title | Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics |
| title_full | Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics |
| title_fullStr | Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics |
| title_full_unstemmed | Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics |
| title_short | Getting Lost in the Cell–Lysosomal Entrapment of Chemotherapeutics |
| title_sort | getting lost in the cell lysosomal entrapment of chemotherapeutics |
| topic | lysosomes lysosomal entrapment chemotherapeutics chemoresistance cancer therapy |
| url | https://www.mdpi.com/2072-6694/12/12/3669 |
| work_keys_str_mv | AT xingjianzhai gettinglostinthecelllysosomalentrapmentofchemotherapeutics AT yassineelhiani gettinglostinthecelllysosomalentrapmentofchemotherapeutics |