Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach
Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-07-01
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| Series: | Translational Neuroscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/tnsci-2022-0231 |
| _version_ | 1811203060449411072 |
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| author | Cicia Alessandra Nociti Viviana Bianco Assunta De Fino Chiara Carlomagno Vincenzo Mirabella Massimiliano Lucchini Matteo |
| author_facet | Cicia Alessandra Nociti Viviana Bianco Assunta De Fino Chiara Carlomagno Vincenzo Mirabella Massimiliano Lucchini Matteo |
| author_sort | Cicia Alessandra |
| collection | DOAJ |
| description | Neurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called “trident sign,” together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis. |
| first_indexed | 2024-04-12T02:49:16Z |
| format | Article |
| id | doaj.art-17f89cb1e5724868b1945be3d0078348 |
| institution | Directory Open Access Journal |
| issn | 2081-6936 |
| language | English |
| last_indexed | 2024-04-12T02:49:16Z |
| publishDate | 2022-07-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Neuroscience |
| spelling | doaj.art-17f89cb1e5724868b1945be3d00783482022-12-22T03:51:02ZengDe GruyterTranslational Neuroscience2081-69362022-07-0113119119710.1515/tnsci-2022-0231Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approachCicia Alessandra0Nociti Viviana1Bianco Assunta2De Fino Chiara3Carlomagno Vincenzo4Mirabella Massimiliano5Lucchini Matteo6Fondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyFondazione Policlinico Universitario Agostino Gemellli IRCCS, UOC Neurologia, Rome, ItalyNeurosarcoidosis is an uncommon and multiform clinical entity. Its presentation as an isolated longitudinal extensive transverse myelitis (LETM) is rare and challenging to identify. We report a case of LETM in a 60-year-old patient with no significant systemic symptoms nor relevant medical history. The peculiar spinal magnetic resonance imaging finding characterized by a posterior and central canal subpial contrast enhancement, the so-called “trident sign,” together with chest computed tomography scan and lymph node biopsy led to the diagnosis of sarcoidosis. We also discuss the main differential diagnoses of LETM and therapeutic options for sarcoidosis-related myelitis.https://doi.org/10.1515/tnsci-2022-0231neurosarcoidosislongitudinally extensive transverse myelitistrident signsarcoidosistreatment |
| spellingShingle | Cicia Alessandra Nociti Viviana Bianco Assunta De Fino Chiara Carlomagno Vincenzo Mirabella Massimiliano Lucchini Matteo Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach Translational Neuroscience neurosarcoidosis longitudinally extensive transverse myelitis trident sign sarcoidosis treatment |
| title | Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach |
| title_full | Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach |
| title_fullStr | Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach |
| title_full_unstemmed | Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach |
| title_short | Neurosarcoidosis presenting as longitudinally extensive myelitis: Diagnostic assessment, differential diagnosis, and therapeutic approach |
| title_sort | neurosarcoidosis presenting as longitudinally extensive myelitis diagnostic assessment differential diagnosis and therapeutic approach |
| topic | neurosarcoidosis longitudinally extensive transverse myelitis trident sign sarcoidosis treatment |
| url | https://doi.org/10.1515/tnsci-2022-0231 |
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