Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer

Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer

Ferroptosis, a genetically and biochemically distinct form of programmed cell death, is characterised by an iron-dependent accumulation of lipid peroxides. Therapy-resistant tumor cells display vulnerability toward ferroptosis. Endoplasmic Reticulum (ER) stress and Unfolded Protein Response (UPR) pl...

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Bibliographic Details
Main Authors: Krishan Kumar Saini, Priyank Chaturvedi, Abhipsa Sinha, Manish Pratap Singh, Muqtada Ali Khan, Ayushi Verma, Mushtaq Ahmad Nengroo, Saumya Ranjan Satrusal, Sanjeev Meena, Akhilesh Singh, Sameer Srivastava, Jayanta Sarkar, Dipak Datta
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Redox Biology
Subjects:
ER stress
UPR
PERK
SLC7A11
Ferroptosis
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002343

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http://www.sciencedirect.com/science/article/pii/S2213231723002343

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