Contribution of the Skin–Gut Axis to Immune-Related Adverse Events with Multi-System Involvement

Contribution of the Skin–Gut Axis to Immune-Related Adverse Events with Multi-System Involvement

Immune-related adverse events (irAEs) frequently complicate treatment with immune checkpoint blockade (ICB) targeting CTLA-4, PD-1, and PD-L1, which are commonly used to treat solid and hematologic malignancies. The skin and gastrointestinal (GI) tract are most frequently affected by irAEs. While ex...

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Bibliographic Details
Main Authors: Alyce M. Kuo, Lukas Kraehenbuehl, Stephanie King, Donald Y. M. Leung, Elena Goleva, Andrea P. Moy, Mario E. Lacouture, Neil J. Shah, David M. Faleck
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
immune checkpoint blockade
cutaneous adverse events
rash
bullous pemphigoid
diarrhea
colitis
Online Access:https://www.mdpi.com/2072-6694/14/12/2995

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