Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2
World Health Organization (WHO) is gathering the latest scientific findings and knowledge on coronavirus disease (SARS-CoV-2) and compiling it in a database. WHO update the database daily from searches of bibliographic databases, hand searches of the table of contents of relevant journals, and the a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Emergency Department of Hospital San Pedro (Logroño, Spain)
2020-03-01
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| Series: | Iberoamerican Journal of Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.5281/zenodo.3715266 |
| _version_ | 1818401448631730176 |
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| author | Kuldeep Singh Patel Jagdish Chandra Rathi Karuna Raghuvanshi Neerupma Dhiman |
| author_facet | Kuldeep Singh Patel Jagdish Chandra Rathi Karuna Raghuvanshi Neerupma Dhiman |
| author_sort | Kuldeep Singh Patel |
| collection | DOAJ |
| description | World Health Organization (WHO) is gathering the latest scientific findings and knowledge on coronavirus disease (SARS-CoV-2) and compiling it in a database. WHO update the database daily from searches of bibliographic databases, hand searches of the table of contents of relevant journals, and the addition of other relevant scientific articles that come to our attention. The entries in the database may not be exhaustive and new research will be added regularly. Nobel coronavirus investigators, the recognition of a nobel coronavirus as the cause of severe acute respiratory syndrome (SARS) was certainly remarkable, yet perhaps not surprising. Advances in the biology of coronaviruses have resulted in greater understanding of their capacity for adaptation to new environments, transspecies infection, and emergence of new diseases. New tools of cell and molecular biology have led to increased understanding of intracellular replication and viral cell biology, and the advent in the past five years of reverse genetic approaches to study coronaviruses has made it possible to begin to define the determinants of viral replication, transpecies adaptation, and human disease. This summary will discuss the basic life cycle and replication of the well-studied coronavirus, mouse hepatitis virus (MHV), identifying the unique characteristics of coronavirus biology and highlighting critical points where research has made significant advances, and which might represent targets for antivirals or vaccines. Areas where rapid progress has been made in SCoV research will be described. Finally, areas of need for research in coronavirus replication, genetics, and pathogenesis will be summarized. |
| first_indexed | 2024-12-14T07:52:38Z |
| format | Article |
| id | doaj.art-17fa0259a7f14f9ab050f3a9f9836ef4 |
| institution | Directory Open Access Journal |
| issn | 2695-5075 |
| language | English |
| last_indexed | 2024-12-14T07:52:38Z |
| publishDate | 2020-03-01 |
| publisher | Emergency Department of Hospital San Pedro (Logroño, Spain) |
| record_format | Article |
| series | Iberoamerican Journal of Medicine |
| spelling | doaj.art-17fa0259a7f14f9ab050f3a9f9836ef42022-12-21T23:10:40ZengEmergency Department of Hospital San Pedro (Logroño, Spain)Iberoamerican Journal of Medicine2695-50752020-03-0122879910.5281/zenodo.3715266Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2Kuldeep Singh Patel0Jagdish Chandra Rathi1Karuna Raghuvanshi2Neerupma Dhiman3Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, IndiaNRI Institute of Pharmaceutical Sciences, 3, Sajjan Singh Nagar Raisen Road, Bhopal, Madhya Pradesh, IndiaNRI Institute of Research &Technology, Sajjan Singh Nagar Raisen Road, Bhopal, Madhya Pradesh, IndiaDepartment of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, IndiaWorld Health Organization (WHO) is gathering the latest scientific findings and knowledge on coronavirus disease (SARS-CoV-2) and compiling it in a database. WHO update the database daily from searches of bibliographic databases, hand searches of the table of contents of relevant journals, and the addition of other relevant scientific articles that come to our attention. The entries in the database may not be exhaustive and new research will be added regularly. Nobel coronavirus investigators, the recognition of a nobel coronavirus as the cause of severe acute respiratory syndrome (SARS) was certainly remarkable, yet perhaps not surprising. Advances in the biology of coronaviruses have resulted in greater understanding of their capacity for adaptation to new environments, transspecies infection, and emergence of new diseases. New tools of cell and molecular biology have led to increased understanding of intracellular replication and viral cell biology, and the advent in the past five years of reverse genetic approaches to study coronaviruses has made it possible to begin to define the determinants of viral replication, transpecies adaptation, and human disease. This summary will discuss the basic life cycle and replication of the well-studied coronavirus, mouse hepatitis virus (MHV), identifying the unique characteristics of coronavirus biology and highlighting critical points where research has made significant advances, and which might represent targets for antivirals or vaccines. Areas where rapid progress has been made in SCoV research will be described. Finally, areas of need for research in coronavirus replication, genetics, and pathogenesis will be summarized.https://doi.org/10.5281/zenodo.3715266sars-cov-2coronavirusantivirals |
| spellingShingle | Kuldeep Singh Patel Jagdish Chandra Rathi Karuna Raghuvanshi Neerupma Dhiman Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 Iberoamerican Journal of Medicine sars-cov-2 coronavirus antivirals |
| title | Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 |
| title_full | Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 |
| title_fullStr | Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 |
| title_full_unstemmed | Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 |
| title_short | Coronavirus (SARS-CoV-2): Preventions, keys to diagnosis and treatment of SARS-CoV-2 |
| title_sort | coronavirus sars cov 2 preventions keys to diagnosis and treatment of sars cov 2 |
| topic | sars-cov-2 coronavirus antivirals |
| url | https://doi.org/10.5281/zenodo.3715266 |
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