The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques
Sperm DNA is known to contribute one half of the genomic material to the offspring. The integrity of sperm DNA is important in fertilization, embryonic and fetal development, and postnatal child well being. The nature has created multiple barriers that allow only the fittest sperm to reach and ferti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Royan Institute (ACECR), Tehran
2006-01-01
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| Series: | Cell Journal |
| Subjects: | |
| Online Access: | http://celljournal.org/library/upload/article/206-215.ps.pdf |
| _version_ | 1828439013365645312 |
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| author | Shahnaz Razavi Mohammad H Nasr-Esfahani Mohammad Mardani |
| author_facet | Shahnaz Razavi Mohammad H Nasr-Esfahani Mohammad Mardani |
| author_sort | Shahnaz Razavi |
| collection | DOAJ |
| description | Sperm DNA is known to contribute one half of the genomic material to the offspring. The integrity of sperm DNA is important in fertilization, embryonic and fetal development, and postnatal child well being. The nature has created multiple barriers that allow only the fittest sperm to reach and fertilize an oocyte. However, assisted reproductive techniques (ART), like IVF and ICSI, may allow sperms with abnormal genomic material to enter the oocyte with minimal effort. This article describes structure of sperm DNA and different mechanism involved in sperm chromatin anomalies and DNA damage. Furthermore, this study elaborates possible sperm selection methods that may improve the outcome of ART. |
| first_indexed | 2024-12-10T20:17:11Z |
| format | Article |
| id | doaj.art-17fb834fc0e7481da575f0ed31eb0577 |
| institution | Directory Open Access Journal |
| issn | 2228-5806 2228-5814 |
| language | English |
| last_indexed | 2024-12-10T20:17:11Z |
| publishDate | 2006-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | Cell Journal |
| spelling | doaj.art-17fb834fc0e7481da575f0ed31eb05772022-12-22T01:35:10ZengRoyan Institute (ACECR), TehranCell Journal2228-58062228-58142006-01-0174206215The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive TechniquesShahnaz RazaviMohammad H Nasr-EsfahaniMohammad MardaniSperm DNA is known to contribute one half of the genomic material to the offspring. The integrity of sperm DNA is important in fertilization, embryonic and fetal development, and postnatal child well being. The nature has created multiple barriers that allow only the fittest sperm to reach and fertilize an oocyte. However, assisted reproductive techniques (ART), like IVF and ICSI, may allow sperms with abnormal genomic material to enter the oocyte with minimal effort. This article describes structure of sperm DNA and different mechanism involved in sperm chromatin anomalies and DNA damage. Furthermore, this study elaborates possible sperm selection methods that may improve the outcome of ART.http://celljournal.org/library/upload/article/206-215.ps.pdfSperm Chromatin AnomaliesARTOutcome |
| spellingShingle | Shahnaz Razavi Mohammad H Nasr-Esfahani Mohammad Mardani The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques Cell Journal Sperm Chromatin Anomalies ART Outcome |
| title | The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques |
| title_full | The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques |
| title_fullStr | The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques |
| title_full_unstemmed | The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques |
| title_short | The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques |
| title_sort | role of sperm chromatin anomalies on the outcome of assisted reproductive techniques |
| topic | Sperm Chromatin Anomalies ART Outcome |
| url | http://celljournal.org/library/upload/article/206-215.ps.pdf |
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