Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya
Objective - to evaluate the association of genetic markers and cardiovascular risk factors with thickening of the intima-media complex among patients with arterial hypertension in the indigenous and non-indigenous population of Mountain Shoriya. Material and methods. The population of Mountain Shori...
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| Format: | Article |
| Language: | Russian |
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IP Morozov P.V.
2018-09-01
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| Series: | Системные гипертензии |
| Subjects: | |
| Online Access: | https://syst-hypertension.ru/2075-082X/article/viewFile/29616/pdf_1 |
| _version_ | 1818526841014583296 |
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| author | T A Mulerova S A Maksimov A N Chigisova M Yu Ogarkov |
| author_facet | T A Mulerova S A Maksimov A N Chigisova M Yu Ogarkov |
| author_sort | T A Mulerova |
| collection | DOAJ |
| description | Objective - to evaluate the association of genetic markers and cardiovascular risk factors with thickening of the intima-media complex among patients with arterial hypertension in the indigenous and non-indigenous population of Mountain Shoriya. Material and methods. The population of Mountain Shoriya in the number of 1409 people was surveyed by a single method (901 people are of indigenous nationality, Shorians, 508 people are non-indigenous 90% of them are Caucasians). Shors are a small Turkic-speaking people. Lipid blood spectrum, fasting plasma glucose, Quetelet index, waist circumference, genetic markers [ACE (I/D, rs4340), AGT (c.803T>C, rs699), AGTR1 (A1166C, rs5186), ADRB1 (p.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677C>T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a)]. Carotid ultrasound was performed. Hypertension was diagnosed according to the National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). The study included 226 Shorians and 124 non-indigenous people with arterial hypertension and an increased thickness of the intima-media complex. The control group consisted of individuals with high blood pressure without atherosclerosis of carotid arteries (81 and 66 people, respectively). Results. It was revealed that such risk factors as gender and age are significantly associated with the thickness of the intima-media complex in the shorthand cohort (OR 1.93; 95% CI 1.03-3.62 and OR 20.01; 95% CI 4.79-83.65) and age - in the cohort of representatives of non-indigenous nationality (OR 3.20; 95% CI 1.39-7.36). An important role in the formation of atherosclerosis of carotid arteries in patients with arterial hypertension has a duration of the course of the disease in both ethnic groups, respectively - OR 2.78; 95% CI (1.45-5.33) and OR 4.22; 95% CI (1.97-9.01). A significantly smaller contribution is made by the genetic component: the rs699 polymorphism of the AGT gene, as in the Shorts (OR 3.51; 95% CI 1.10-11.25), and in non-indigenous residents (OR 4.90; 95% CI 1.15-20.92) and polymorphism rs1801133 of the MTHFR gene only in persons of indigenous nationality (OR 10.80; 95% CI 2.35-49.70). Conclusion. Timely establishment of risk factors for subclinical atherosclerosis in hypertension and their correction depending on the national trait will help prevent the progression of the process, reverse it, and reduce the risk of complications, premature disability and mortality. |
| first_indexed | 2024-12-11T06:28:24Z |
| format | Article |
| id | doaj.art-17fd35dfc8444450a4feb4dc8b94bceb |
| institution | Directory Open Access Journal |
| issn | 2075-082X 2542-2189 |
| language | Russian |
| last_indexed | 2024-12-11T06:28:24Z |
| publishDate | 2018-09-01 |
| publisher | IP Morozov P.V. |
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| series | Системные гипертензии |
| spelling | doaj.art-17fd35dfc8444450a4feb4dc8b94bceb2022-12-22T01:17:36ZrusIP Morozov P.V.Системные гипертензии2075-082X2542-21892018-09-01153273110.26442/2075-082X_2018.3.27-3126644Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain ShoriyaT A Mulerova0S A Maksimov1A N Chigisova2M Yu Ogarkov3Research Institute for Complex Issues of Cardiovascular Diseases; Novokuznetsk State Institute for Postgraduate Training of Physicians - a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular DiseasesResearch Institute for Complex Issues of Cardiovascular Diseases; Novokuznetsk State Institute for Postgraduate Training of Physicians - a branch of Russian Medical Academy of Continuous Professional Education of the Ministry of Health of the Russian FederationObjective - to evaluate the association of genetic markers and cardiovascular risk factors with thickening of the intima-media complex among patients with arterial hypertension in the indigenous and non-indigenous population of Mountain Shoriya. Material and methods. The population of Mountain Shoriya in the number of 1409 people was surveyed by a single method (901 people are of indigenous nationality, Shorians, 508 people are non-indigenous 90% of them are Caucasians). Shors are a small Turkic-speaking people. Lipid blood spectrum, fasting plasma glucose, Quetelet index, waist circumference, genetic markers [ACE (I/D, rs4340), AGT (c.803T>C, rs699), AGTR1 (A1166C, rs5186), ADRB1 (p.145A>G, Ser49Gly, rs1801252), ADRA2B (I/D, rs28365031), MTHFR (c.677C>T, Ala222Val, rs1801133) and NOS3 (VNTR, 4b/4a)]. Carotid ultrasound was performed. Hypertension was diagnosed according to the National Guidelines of the Russian Society of Cardiology/the Russian Medical Society on Arterial Hypertension (2010). The study included 226 Shorians and 124 non-indigenous people with arterial hypertension and an increased thickness of the intima-media complex. The control group consisted of individuals with high blood pressure without atherosclerosis of carotid arteries (81 and 66 people, respectively). Results. It was revealed that such risk factors as gender and age are significantly associated with the thickness of the intima-media complex in the shorthand cohort (OR 1.93; 95% CI 1.03-3.62 and OR 20.01; 95% CI 4.79-83.65) and age - in the cohort of representatives of non-indigenous nationality (OR 3.20; 95% CI 1.39-7.36). An important role in the formation of atherosclerosis of carotid arteries in patients with arterial hypertension has a duration of the course of the disease in both ethnic groups, respectively - OR 2.78; 95% CI (1.45-5.33) and OR 4.22; 95% CI (1.97-9.01). A significantly smaller contribution is made by the genetic component: the rs699 polymorphism of the AGT gene, as in the Shorts (OR 3.51; 95% CI 1.10-11.25), and in non-indigenous residents (OR 4.90; 95% CI 1.15-20.92) and polymorphism rs1801133 of the MTHFR gene only in persons of indigenous nationality (OR 10.80; 95% CI 2.35-49.70). Conclusion. Timely establishment of risk factors for subclinical atherosclerosis in hypertension and their correction depending on the national trait will help prevent the progression of the process, reverse it, and reduce the risk of complications, premature disability and mortality.https://syst-hypertension.ru/2075-082X/article/viewFile/29616/pdf_1mountain shoriyaatherosclerosis of carotid arteriesfactors of cardiovascular riskpolymorphism of candidate genes |
| spellingShingle | T A Mulerova S A Maksimov A N Chigisova M Yu Ogarkov Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya Системные гипертензии mountain shoriya atherosclerosis of carotid arteries factors of cardiovascular risk polymorphism of candidate genes |
| title | Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya |
| title_full | Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya |
| title_fullStr | Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya |
| title_full_unstemmed | Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya |
| title_short | Influence of allure polymorphism distribution of arterial hypertensions gene-candidates jointly with cardiovascular risk factors on change of thickness of intima-media complex among patients with higher arterial pressure living in Mountain Shoriya |
| title_sort | influence of allure polymorphism distribution of arterial hypertensions gene candidates jointly with cardiovascular risk factors on change of thickness of intima media complex among patients with higher arterial pressure living in mountain shoriya |
| topic | mountain shoriya atherosclerosis of carotid arteries factors of cardiovascular risk polymorphism of candidate genes |
| url | https://syst-hypertension.ru/2075-082X/article/viewFile/29616/pdf_1 |
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