Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome
ABSTRACTPhysical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes....
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Epigenetics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15592294.2024.2305082 |
| _version_ | 1797349556519698432 |
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| author | Cristiana Libardi Miranda Furtado Megan Hansen Gislaine Satyko Kogure Victor Barbosa Ribeiro Nathanael Taylor Murilo Racy Soares Rui Alberto Ferriani Kenneth Ivan Aston Timothy Jenkins Rosana Maria dos Reis |
| author_facet | Cristiana Libardi Miranda Furtado Megan Hansen Gislaine Satyko Kogure Victor Barbosa Ribeiro Nathanael Taylor Murilo Racy Soares Rui Alberto Ferriani Kenneth Ivan Aston Timothy Jenkins Rosana Maria dos Reis |
| author_sort | Cristiana Libardi Miranda Furtado |
| collection | DOAJ |
| description | ABSTRACTPhysical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes. |
| first_indexed | 2024-03-08T12:32:01Z |
| format | Article |
| id | doaj.art-17fdfff8c63640a3b4e651cc6a9ef748 |
| institution | Directory Open Access Journal |
| issn | 1559-2294 1559-2308 |
| language | English |
| last_indexed | 2024-03-08T12:32:01Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Epigenetics |
| spelling | doaj.art-17fdfff8c63640a3b4e651cc6a9ef7482024-01-21T19:28:42ZengTaylor & Francis GroupEpigenetics1559-22941559-23082024-12-0119110.1080/15592294.2024.2305082Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndromeCristiana Libardi Miranda Furtado0Megan Hansen1Gislaine Satyko Kogure2Victor Barbosa Ribeiro3Nathanael Taylor4Murilo Racy Soares5Rui Alberto Ferriani6Kenneth Ivan Aston7Timothy Jenkins8Rosana Maria dos Reis9Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USADepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USADepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilDepartment of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USADepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USADepartment of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, BrazilABSTRACTPhysical activity is a first-line treatment for polycystic ovary syndrome (PCOS). Resistance or aerobic exercise improves metabolic complications, reproductive outcomes, and quality of life in PCOS. DNA methylation reprogramming during exercise may be the major modifier behind these changes. We sought to evaluate genome-wide DNA methylation changes after supervised resistance and aerobic exercise in women with PCOS. Exercises were performed in 56 women with PCOS (resistance, n = 30; aerobic, n = 26), for 16 weeks (wks), three times per week, in 50-minute to one-hour sessions. Anthropometric indices and hormonal and metabolic parameters were measured before and after training. Genome-wide leukocyte DNA methylation was analysed by Infinium Human MethylationEPIC 850K BeadChip microarrays (Illumina). Both resistance and aerobic exercise improved anthropometric indices, metabolic dysfunction, and hyperandrogenism in PCOS after the training programme, but no differences were observed between the two exercises. Resistance and aerobic exercise increased genome-wide DNA methylation, although resistance changed every category in the CpG island context (islands, shores, shelve, and open sea), whereas aerobic exercise altered CpG shores and the open sea. Using a stringent FDR (>40), 6 significantly differentially methylated regions (DMRs) were observed in the resistance exercise cohort and 14 DRMs in the aerobic cohort, all of which were hypermethylated. The increase in genome-wide DNA methylation may be related to the metabolic and hormonal changes observed in PCOS after resistance and aerobic exercise. Since the mammalian genome is hypermethylated globally to prevent genomic instability and ageing, resistance and aerobic exercise may promote health and longevity through environmentally induced epigenetic changes.https://www.tandfonline.com/doi/10.1080/15592294.2024.2305082Polycystic ovary syndromephysical activityaerobic trainingresistance trainingDNA methylation |
| spellingShingle | Cristiana Libardi Miranda Furtado Megan Hansen Gislaine Satyko Kogure Victor Barbosa Ribeiro Nathanael Taylor Murilo Racy Soares Rui Alberto Ferriani Kenneth Ivan Aston Timothy Jenkins Rosana Maria dos Reis Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome Epigenetics Polycystic ovary syndrome physical activity aerobic training resistance training DNA methylation |
| title | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome |
| title_full | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome |
| title_fullStr | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome |
| title_full_unstemmed | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome |
| title_short | Resistance and aerobic training increases genome-wide DNA methylation in women with polycystic ovary syndrome |
| title_sort | resistance and aerobic training increases genome wide dna methylation in women with polycystic ovary syndrome |
| topic | Polycystic ovary syndrome physical activity aerobic training resistance training DNA methylation |
| url | https://www.tandfonline.com/doi/10.1080/15592294.2024.2305082 |
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