Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis
BackgroundExposure to recurrent infections in childhood was linked to an increased risk of cancer in adulthood. There is also evidence that a history of tonsillectomy, a procedure often performed in children with recurrent infections, is linked to an increased risk of leukemia and Hodgkin lymphoma....
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.925596/full |
| _version_ | 1828786550925688832 |
|---|---|
| author | Salah Eddine O. Kacimi Anas Elgenidy Huzaifa Ahmad Cheema Mounir Ould Setti Mounir Ould Setti Atulya Aman Khosla Amira Yasmine Benmelouka Mohammad Aloulou Kawthar Djebabria Laila Salah Shamseldin Omar Riffi Nabil Smain Mesli Nabil Smain Mesli Hanane Z. Sekkal Ahmed M. Afifi Jaffer Shah Sherief Ghozy Sherief Ghozy |
| author_facet | Salah Eddine O. Kacimi Anas Elgenidy Huzaifa Ahmad Cheema Mounir Ould Setti Mounir Ould Setti Atulya Aman Khosla Amira Yasmine Benmelouka Mohammad Aloulou Kawthar Djebabria Laila Salah Shamseldin Omar Riffi Nabil Smain Mesli Nabil Smain Mesli Hanane Z. Sekkal Ahmed M. Afifi Jaffer Shah Sherief Ghozy Sherief Ghozy |
| author_sort | Salah Eddine O. Kacimi |
| collection | DOAJ |
| description | BackgroundExposure to recurrent infections in childhood was linked to an increased risk of cancer in adulthood. There is also evidence that a history of tonsillectomy, a procedure often performed in children with recurrent infections, is linked to an increased risk of leukemia and Hodgkin lymphoma. Tonsillectomy could be directly associated with cancer risk, or it could be a proxy for another risk factor such as recurrent infections and chronic inflammation. Nevertheless, the role of recurrent childhood infections and tonsillectomy on the one hand, and the risk of breast cancer (BC) in adulthood remain understudied. Our study aims to verify whether a history of tonsillectomy increases the risk of BC in women.MethodsA systematic review was performed using PubMed, Google Scholar, Scopus, Embase, and Web of Science databases from inception to January 25, 2022, to identify the studies which assessed the association between the history of tonsillectomy and BC in females. Odds ratio (OR) was calculated using the random/fixed-effects models to synthesize the associations between tonsillectomy and BC risk based on heterogeneity.ResultsEight studies included 2252 patients with breast cancer of which 1151 underwent tonsillectomy and 5314 controls of which 1725 had their tonsils removed. Patients with a history of tonsillectomy showed a higher subsequent risk of developing BC (OR, 1.24; 95% CI: 1.11-1.39) as compared to patients without a history of tonsillectomy. Influence analyses showed that no single study had a significant effect on the overall estimate or the heterogeneity.ConclusionsOur study revealed that a history of tonsillectomy is associated with an increased risk of breast cancer. These findings underscore the need for frequent follow-ups and screening of tonsillectomy patients to assess for the risk of BC. |
| first_indexed | 2024-12-12T00:13:15Z |
| format | Article |
| id | doaj.art-1801108d3af340f6be600a31a1bc6239 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T00:13:15Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-1801108d3af340f6be600a31a1bc62392022-12-22T00:44:53ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-07-011210.3389/fonc.2022.925596925596Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysisSalah Eddine O. Kacimi0Anas Elgenidy1Huzaifa Ahmad Cheema2Mounir Ould Setti3Mounir Ould Setti4Atulya Aman Khosla5Amira Yasmine Benmelouka6Mohammad Aloulou7Kawthar Djebabria8Laila Salah Shamseldin9Omar Riffi10Nabil Smain Mesli11Nabil Smain Mesli12Hanane Z. Sekkal13Ahmed M. Afifi14Jaffer Shah15Sherief Ghozy16Sherief Ghozy17Faculty of Medicine, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, AlgeriaFaculty of Medicine, Cairo University, Cairo, EgyptDepartment of Medicine, King Edward Medical University, Lahore, PakistanInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, FinlandGlobal Database Studies, IQVIA, Espoo, FinlandMaulana Azad Medical College, New Delhi, IndiaFaculty of Medicine, University of Algiers, Algiers, AlgeriaFaculty of Medicine, University of Aleppo, Aleppo, SyriaFaculty of Medicine, University of Annaba, Annaba, Algeria0Faculty of Medicine, Tanta University, Tanta, EgyptFaculty of Medicine, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, AlgeriaFaculty of Medicine, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, Algeria1Department of Surgery A, University-Hospital Center (CHU) of Tlemcen, Tlemcen, AlgeriaFaculty of Medicine, Abou-Bekr Belkaid University of Tlemcen, Tlemcen, Algeria2Division of Gastroenterology, Baylor College of Medicine, Houston, TX, United States3New York State Department of Health, Albany, NY, United States4Department of Radiology, Mayo Clinic, Rochester, MN, United States5Nuffield Department of Primary Care Health Sciences and Department for Continuing Education (EBHC program), Oxford University, Oxford, United KingdomBackgroundExposure to recurrent infections in childhood was linked to an increased risk of cancer in adulthood. There is also evidence that a history of tonsillectomy, a procedure often performed in children with recurrent infections, is linked to an increased risk of leukemia and Hodgkin lymphoma. Tonsillectomy could be directly associated with cancer risk, or it could be a proxy for another risk factor such as recurrent infections and chronic inflammation. Nevertheless, the role of recurrent childhood infections and tonsillectomy on the one hand, and the risk of breast cancer (BC) in adulthood remain understudied. Our study aims to verify whether a history of tonsillectomy increases the risk of BC in women.MethodsA systematic review was performed using PubMed, Google Scholar, Scopus, Embase, and Web of Science databases from inception to January 25, 2022, to identify the studies which assessed the association between the history of tonsillectomy and BC in females. Odds ratio (OR) was calculated using the random/fixed-effects models to synthesize the associations between tonsillectomy and BC risk based on heterogeneity.ResultsEight studies included 2252 patients with breast cancer of which 1151 underwent tonsillectomy and 5314 controls of which 1725 had their tonsils removed. Patients with a history of tonsillectomy showed a higher subsequent risk of developing BC (OR, 1.24; 95% CI: 1.11-1.39) as compared to patients without a history of tonsillectomy. Influence analyses showed that no single study had a significant effect on the overall estimate or the heterogeneity.ConclusionsOur study revealed that a history of tonsillectomy is associated with an increased risk of breast cancer. These findings underscore the need for frequent follow-ups and screening of tonsillectomy patients to assess for the risk of BC.https://www.frontiersin.org/articles/10.3389/fonc.2022.925596/fullbreasttonsillectomymeta-analysisriskoral infection |
| spellingShingle | Salah Eddine O. Kacimi Anas Elgenidy Huzaifa Ahmad Cheema Mounir Ould Setti Mounir Ould Setti Atulya Aman Khosla Amira Yasmine Benmelouka Mohammad Aloulou Kawthar Djebabria Laila Salah Shamseldin Omar Riffi Nabil Smain Mesli Nabil Smain Mesli Hanane Z. Sekkal Ahmed M. Afifi Jaffer Shah Sherief Ghozy Sherief Ghozy Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis Frontiers in Oncology breast tonsillectomy meta-analysis risk oral infection |
| title | Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis |
| title_full | Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis |
| title_fullStr | Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis |
| title_short | Prior Tonsillectomy and the Risk of Breast Cancer in Females: A Systematic Review and Meta-analysis |
| title_sort | prior tonsillectomy and the risk of breast cancer in females a systematic review and meta analysis |
| topic | breast tonsillectomy meta-analysis risk oral infection |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.925596/full |
| work_keys_str_mv | AT salaheddineokacimi priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT anaselgenidy priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT huzaifaahmadcheema priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT mounirouldsetti priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT mounirouldsetti priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT atulyaamankhosla priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT amirayasminebenmelouka priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT mohammadaloulou priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT kawthardjebabria priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT lailasalahshamseldin priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT omarriffi priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT nabilsmainmesli priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT nabilsmainmesli priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT hananezsekkal priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT ahmedmafifi priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT jaffershah priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT sheriefghozy priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis AT sheriefghozy priortonsillectomyandtheriskofbreastcancerinfemalesasystematicreviewandmetaanalysis |